Abstract | PURPOSE OF REVIEW: RECENT FINDINGS:
Allergic reactions to quinolones can be immediate or delayed, being anaphylaxis and maculopapular exanthema respectively the most frequent clinical entities. A precise diagnosis is particularly difficult since clinical history is often unreliable, skin tests can induce false-positive results, and commercial in vitro test are not well validated. Therefore, drug provocation testing is considered the gold standard to establish diagnosis, which is not a risk-free procedure. Cross-reactivity between quinolones is difficult to predict due to the small number of patients included in the few published studies. Moreover, hypersensitivity to quinolones has also been associated with beta-lactam and neuromuscular blocking agent allergies, although further studies are needed to understand the underlying mechanisms. Avoidance of the culprit quinolone is indicated in patients with a diagnosis of hypersensitivity to these drugs. When quinolone treatment is the only therapeutic option available, desensitization is necessary. This review summarizes the complex diagnostic approach and management of allergic reactions to quinolones.
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Authors | Inmaculada Doña, Esther Moreno, Natalia Pérez-Sánchez, Inmaculada Andreu, Dolores Hernández Fernandez de Rojas, María José Torres |
Journal | Current allergy and asthma reports
(Curr Allergy Asthma Rep)
Vol. 17
Issue 8
Pg. 56
(Aug 2017)
ISSN: 1534-6315 [Electronic] United States |
PMID | 28752367
(Publication Type: Journal Article, Review)
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Chemical References |
- Anti-Bacterial Agents
- Quinolones
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Topics |
- Anti-Bacterial Agents
(adverse effects, chemistry, immunology)
- Cross Reactions
- Drug Hypersensitivity
(diagnosis, epidemiology, etiology, therapy)
- Humans
- Molecular Structure
- Quinolones
(adverse effects, chemistry, immunology)
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