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Neuromuscular Blocking Agents

Drugs that interrupt transmission of nerve impulses at the skeletal neuromuscular junction. They can be of two types, competitive, stabilizing blockers (NEUROMUSCULAR NONDEPOLARIZING AGENTS) or noncompetitive, depolarizing agents (NEUROMUSCULAR DEPOLARIZING AGENTS). Both prevent acetylcholine from triggering the muscle contraction and they are used as anesthesia adjuvants, as relaxants during electroshock, in convulsive states, etc.
Also Known As:
Neuromuscular Blockers; Agent, Neuromuscular Blocking; Agents, Neuromuscular Blocking; Blocker, Neuromuscular; Blockers, Neuromuscular; Blocking Agent, Neuromuscular; Blocking Agents, Neuromuscular; Neuromuscular Blocker; Neuromuscular Blocking Agent
Networked: 904 relevant articles (21 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Papazian, Laurent: 14 articles (12/2020 - 01/2004)
2. Johansson, S G O: 10 articles (05/2017 - 04/2005)
3. Eikermann, Matthias: 9 articles (01/2021 - 06/2007)
4. Mertes, P M: 9 articles (11/2018 - 10/2001)
5. Florvaag, E: 9 articles (05/2017 - 04/2005)
6. Hraiech, Sami: 8 articles (12/2020 - 10/2012)
7. Tobias, Joseph D: 7 articles (04/2022 - 03/2007)
8. Ebo, Didier G: 7 articles (01/2021 - 08/2007)
9. Mehta, Sangeeta: 7 articles (01/2021 - 02/2006)
10. Forel, Jean-Marie: 7 articles (12/2017 - 01/2004)

Related Diseases

1. Critical Illness (Critically Ill)
2. Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome)
3. Paralysis (Palsy)
4. Hypersensitivity (Allergy)
5. Ventilator-Induced Lung Injury
02/26/2023 - "Support mode during invasive mechanical ventilation offers potential benefits such as conserving diaphragmatic motility, sidestepping the negative consequences of the longer usage of neuromuscular blockers, and limiting the occurrence of ventilator-induced lung injury (VILI). "
06/01/2018 - "The use of neuromuscular blocking agents may limit hypoxemia while preventing ventilator-induced lung injury. "
12/01/2019 - "Of the 27 trials reporting reduced mortality, six had assessed interventions likely to decrease ventilator-induced lung injury, including low tidal volume, prone position, and neuromuscular blockers, demonstrating the negative effects of mechanical ventilation strategies or improved process of care rather than positive effects of new therapies. "
09/16/2010 - "In patients undergoing mechanical ventilation for the acute respiratory distress syndrome (ARDS), neuromuscular blocking agents may improve oxygenation and decrease ventilator-induced lung injury but may also cause muscle weakness. "
04/01/2021 - "This article reviews the concept of "baby lung" in ARDS and the current evidence for the use of lung protective ventilation, prevention of ventilator-induced lung injury, recommended modes of mechanical ventilation, ideal ventilatory parameters (tidal volume, positive end expiratory pressure, plateau pressure, respiratory rate, fractional inspired oxygen concentration), and use of adjuncts (prone positioning, neuromuscular blocking agents) during the ECMO course."

Related Drugs and Biologics

1. Succinylcholine (Suxamethonium Chloride)
2. Adrenal Cortex Hormones (Corticosteroids)
3. Atracurium (Tracrium)
4. cisatracurium (Nimbex)
5. Opioid Analgesics (Opioids)
6. Vecuronium Bromide (Vecuronium)
7. Type A Botulinum Toxins (Botox)
8. beta-Lactams
9. Benzodiazepines
10. Lithium

Related Therapies and Procedures

1. Artificial Respiration (Mechanical Ventilation)
2. General Anesthesia
3. Mechanical Ventilators (Ventilator)
4. Therapeutics
5. Anesthesia