Abstract | INTRODUCTION: PATIENTS AND METHODS: We performed a retrospective 2-center study of 406 patients who had undergone neoadjuvant chemotherapy (NAC) followed by surgery from 2007 to 2014. The regimen included 4 cycles of anthracycline plus cyclophosphamide, followed by 4 cycles of taxane. We investigated the presence and degree of LE using a telephone questionnaire assessment. Weight changes were calculated at each cycle of NAC, and the baseline and preoperative body weights were used to calculate the rate of change to account for the change in weight before and after NAC. RESULTS: Of the 406 patients, 270 answered the questionnaires, of whom 97 (35.9%) experienced LE. The increase in body weight was significant during the 4 cycles of taxane, but the change in weight was not significant during the 4 cycles of anthracycline plus cyclophosphamide. The change in body weight was most significant just after the fourth cycle of taxane (P < .001). The body mass index (BMI) was an independent factor of LE occurrence on multivariate analysis. However, the change in body weight was not a significant factor for the incidence of LE. CONCLUSION: Because a BMI ≥ 25 kg/m2 was an independent factor of LE occurrence on multivariate analysis, patients with a preoperative BMI ≥ 25 kg/m2 should be closely monitored for LE given their increased risk, and monitoring and education should be initiated before surgery and continued throughout the course of NAC.
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Authors | Sungmin Park, Jeong Eon Lee, Jonghan Yu, Hyun-June Paik, Jai Min Ryu, Isaac Kim, Soo Youn Bae, Se Kyung Lee, Seok Won Kim, Seok Jin Nam, Eun-Kyu Kim, Eunyoung Kang, Eun Joo Yang |
Journal | Clinical breast cancer
(Clin Breast Cancer)
Vol. 18
Issue 1
Pg. e49-e54
(02 2018)
ISSN: 1938-0666 [Electronic] United States |
PMID | 28705541
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Bridged-Ring Compounds
- Taxoids
- taxane
- Epirubicin
- Cyclophosphamide
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Topics |
- Adult
- Aged
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Body Mass Index
- Body Weight
(drug effects)
- Breast Neoplasms
(complications, therapy)
- Bridged-Ring Compounds
(adverse effects)
- Cyclophosphamide
(adverse effects)
- Epirubicin
(adverse effects)
- Female
- Humans
- Incidence
- Lymphedema
(epidemiology, etiology)
- Mastectomy
- Middle Aged
- Neoadjuvant Therapy
(adverse effects, methods)
- Patient Education as Topic
- Retrospective Studies
- Risk Factors
- Self Report
- Taxoids
(adverse effects)
- Young Adult
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