Lymphedema (Milroy Disease)

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775 relevant articles (61 outcomes, 78 trials/studies) found for this Disease

Description: Edema due to obstruction of lymph vessels or disorders of the lymph nodes.

Also Known As:

Milroy Disease; Disease, Milroy; Disease, Milroy's; Lymphedemas; Milroys Disease; Milroy's Disease

Relationship Network

Disease Context: Research Results

Hemic and Lymphatic Diseases

Lymphatic Diseases: 1961

Lymphedema: 775

Elephantiasis: 154

Related Diseases

1.	Breast Neoplasms (Breast Cancer)
2.	Neoplasms (Cancer)
3.	Edema
4.	Infection
5.	Kaposi Sarcoma (Kaposi's Sarcoma)

Experts

1.	Brorson, H: 4 articles (06/2008 - 01/2000)
2.	Bi, Yushun: 2 articles (07/2008 - 04/2008)
3.	Dong, Ping: 2 articles (07/2008 - 04/2008)
4.	Fang, Yunhai: 2 articles (07/2008 - 04/2008)
5.	Gao, Jie: 2 articles (07/2008 - 04/2008)
6.	Liu, Yanli: 2 articles (07/2008 - 04/2008)
7.	Liu, Zhiyu: 2 articles (07/2008 - 04/2008)
8.	Ding, Zhaoxi: 2 articles (07/2008 - 04/2008)
9.	Tian, Hua: 2 articles (07/2008 - 04/2008)
10.	Liu, Rong: 2 articles (07/2008 - 04/2008)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Lymphedema:

1.	Vascular Endothelial Growth Factor CIBA 05/01/2008 - "RESULTS: Compared with control group, overexpression of VEGF-C enhanced lymphangiogenesis in vivo and mouse tail skin suffering chronic obstructive lymphedema was improved by VEGF-C gene significantly. " 05/01/2008 - "OBJECTIVE: To study the therapeutic effect of vascular endothelial growth factor C(VEGF-C) gene for chronic obstructive lymphedema in mouse tail model which may provide a new treatment for lymphedema. " 03/01/2008 - "VEGF-C protein improved lymphedema at 15 days [reducing dermal thickness from 742 +/- 105 to 559 +/- 141 microm with 95% confidence intervals (CIs), P < 0.05] without increasing lymphatic capillary coverage (11.6 +/- 6.4% following VEGF-C treatment relative to 9.6 +/- 6.2% with 95% CIs, P > 0.50). " 07/01/2008 - "Our results indicate that VEGF-C gene therapy has produced new lymphatic vessels which may have improved functional lymphatic drainage to reduce lymphedema volume in our model." 04/01/2008 - "Our results indicate that VEGF-C gene therapy has produced new lymphatic vessels which may have improved functional lymphatic drainage to reduce lymphedema volume in our model." Order ALL the reference details at left...
2.	coumarinIBA 03/01/1999 - "In both groups, the volume of arm lymphedema decreased (14.9% in Group A and 13.2% in Group B) (N.S.), the overall clinical score improved (12.9 +/- 4.3 to 5.7 +/- 3.5 in Group A and from 11.7 +/- 3.7 to 4.7 +/- 3.9 in Group B) (N.S.), and the overall efficacy of coumarin was similarly good or excellent (71.9% in Group A and 68.6% in Group B) (N.S.). " 01/01/1990 - "A randomized double blind study versus placebo has confirmed the occurrence of significant improvement of these mild swelling cases, and recommend the use of coumarin as supplemental therapy in mild lymphedema." 01/01/2005 - "However, it seems without doubt that the majority of studies conducted thus far suggest that coumarin (and other benzopyrones, i.e., the ruto-sides, which do not have hepatotoxic effects and which are often discussed in aggregate with coumarin) is effective in treating lymphedema, particularly when used in conjunction with complex physical therapy. " 02/04/1999 - "Coumarin has been reported to be effective for the treatment of women with lymphedema; we undertook a study in which we attempted to replicate those findings. " 09/01/1996 - "EXPERIMENTAL: A study was performed on the use of an ideal phlebolymphological association (Tonka Beans, Gingko Biloba, Melilotus Officinalis) as a practical standpoint in the treatment of lymphedema of lower limbs in order to create an efficacious dose of Coumarin, Benzopyrones and Ginkolidi. " Order ALL the reference details at left...
3.	Sodium Selenite (Selenite)IBA 09/01/2005 - "A significant reduction of lymphedema occurred in the sodium selenite-treated group. " 06/01/2007 - "Schrauzer, Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review, Am. J. " 07/01/2004 - "CONCLUSION: Our results suggest a short positive effect of sodium selenite on secondary head and neck lymphedema caused by radiotherapy alone or in combination with surgery." 05/01/2003 - "Additionally, our results suggest that sodium selenite has a positive effect on secondary-developing lymphedema caused by radiation therapy alone or by irradiation after surgery." 08/01/2000 - "Treatment of secondary lymphedema of the arm with physical decongestive therapy and sodium selenite: a review." Order ALL the reference details at left...
4.	Cytidine Diphosphate (CDP)IBA 03/15/2004 - "CONCLUSIONS: With a decrease in lymphedema of 60%, CDP may provide relief for patients with lymphedema following groin dissection. " 12/01/2007 - "CONCLUSION: In a study of Japanese women with lymphedema, CDP comprising a two-phase treatment program was clearly effective." 03/01/2000 - "Because little is known of its possible mode of action on a molecular level, this preliminary study evaluated CDP in patients with peripheral leg lymphedema as to the potential role of gene expression in the inflammatory response. " 12/15/1998 - "This was done by establishing a network of outpatient CDP clinics where patients can be treated effectively and a training school, the Lerner Lymphedema Services Academy of Lymphatic Studies (the Lerner School), where physicians and therapists can be trained in all facets of the lymphedema problem and where the CDP method with all of its components is taught. " 06/01/2008 - "In 83 patients with stage II unilateral secondary extremity lymphedema (31 upper extremities and 52 lower extremities), the daily changes in the volume of affected extremities during the treatment phase of CDP were prospectively investigated. " Order ALL the reference details at left...
5.	CosmeticsIBA 08/01/2006 - "CONCLUSIONS: The modified Charles procedure for the treatment of penoscrotal lymphedema is easily reproducible and allows better local hygiene, easier ambulation, voiding in the standing position, resuming sexual intercourse, and finally, better cosmetic results in the affected area with remarkable improvement in quality of life." 05/01/2005 - "Even medical management of penoscrotal lymphedema is not effective for most patients, surgery is a safe and effective procedure that gives excellent functional and cosmetic results." 04/01/2007 - "Penile and scrotal lymphedema causes significant functional, cosmetic and psychological problems. " 07/01/2005 - "The sentinel node (SN) procedure avoids lymphedema in the breast, which might influence cosmetic outcome. " 09/01/2003 - "CONCLUSIONS: When patients with lymphedema of the external genitalia require surgery and are properly selected for the appropriate procedure, the functional and cosmetic results are excellent and patient rehabilitation is likely." Order ALL the reference details at left...
6.	AntibodiesIBA 05/01/2005 - "Supporting evidence is provided by experience in the operative treatment of extremity lymphedema, PET-CT examinations, radionuclear lymphography, and scientific investigations using antibodies specifically directed at the elements of the lymph vascular system." 08/01/2001 - "WSP-specific antibody responses were temporally associated with increases in antifilarial IgG1 antibodies as well as lymphedema development. " 09/01/2003 - "As opposed to antifilarial antibody responses, which were largely influenced by the patient's infection status, the prevalence and levels of anti-WSP immunoglobulin G (IgG) antibodies among individuals with lymphedema or hydrocele were significantly greater than those in gender- and infection-matched individuals without disease. " 06/01/1998 - "This study examined acute-convalescent changes in diagnostic anti-streptococcal antibodies by the anti-streptolysin O (ASO) and anti-DNAase B (ADAB) tests among patients (n 28) with lymphedema and recurrent erisipela of the lower limb, comparing them with endemic normal control residents (n=25). " 03/01/2008 - "The role of vascular endothelial growth factor-C (VEGF-C)/VEGF receptor (VEGFR)-3 signaling in lymphedema resolution was investigated by exogenous administration of VEGF-C or neutralizing antibodies against VEGFR-3. " Order ALL the reference details at left...
7.	Penicillins (Penicillin)FDA Link 06/01/2005 - "In this study, we retrospectively evaluated a self/community-selected group of patients with lymphedema of the lower limbs with respect to the efficacy of long-acting penicillin in preventing episodes of DLA. " 06/01/2005 - "The effectiveness of long-acting penicillin (penidur) in preventing recurrences of dermatolymphangioadenitis(DLA) and controlling skin, deep tissues, and lymph bacterial flora in patients with "filarial" lymphedema." 04/01/1989 - "The vaccine has proved to be equivalent to the penicillin therapy and can be recommended as a real alternative to it for prevention of further infections and late sequelae, especially those of chronic lymphedema. " 09/01/1996 - "We investigated the clinical course of lymphedema with respect to the prevalence of DLA in patients receiving injections of long-acting penicillin (benzathine penicillin). " Order ALL the reference details at left...
8.	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 09/12/2006 - "The goal of the present study was to investigate the therapeutic efficacy of hepatocyte growth factor (HGF) in animal models of lymphedema. " 09/12/2006 - "Transfection of human hepatocyte growth factor gene ameliorates secondary lymphedema via promotion of lymphangiogenesis." 01/01/2008 - "Recent observations suggested that hepatocyte growth factor/high affinity hepatocyte growth factor receptor (HGF/MET) were new candidate lymphedema genes. " Order ALL the reference details at left...
9.	Benzathine Penicillin G (LPG)FDA Link 09/01/2007 - "Two treatment protocols are presented using the LPG Endermologie system in combination with compression bandaging as a new treatment option for secondary arm lymphedema. " 09/01/1996 - "Episodic dermatolymphangioadenitis (DLA) in patients with lymphedema of the lower extremities before and after administration of benzathine penicillin: a preliminary study." 09/01/1996 - "We investigated the clinical course of lymphedema with respect to the prevalence of DLA in patients receiving injections of long-acting penicillin (benzathine penicillin). " Order ALL the reference details at left...
10.	Diosmin (Daflon)IBA 09/01/1995 - "Evaluation by lymphoscintigraphy of the effect of a micronized flavonoid fraction (Daflon 500 mg) in the treatment of upper limb lymphedema." 01/01/1997 - "Efficacy of Daflon 500 mg in the treatment of lymphedema (secondary to conventional therapy of breast cancer)." 01/01/1997 - "To assess the activity of a purified, micronized, flavonoidic fraction (Dios; Daflon 500 mg) on upper limb lymphedema occurring after breast cancer therapy, a monocenter, randomized, double-blind, parallel group vs placebo (Plac) trial was carried out. " Order ALL the reference details at left...*

Therapies and Procedures

1.	Massage (Reflexology) 03/01/2005 - "In patient 1 lymphedema improved significantly following SRL reduction and lymphatic drainage massage therapy. " 01/17/2001 - "Nonpharmacologic treatments, such as massage and exercise, have been shown to be effective therapies for lymphedema, but the effect of pharmacologic interventions remains uncertain. " 07/01/1981 - "[Experimental studies on the efficacy of pressure wave massage (Lymphapress) in lymphedema]" 01/01/2006 - "We have undertaken a prospective, randomized, crossover study of the efficacy of the Flexitouch, when compared to massage, in the self-administered maintenance therapy of lymphedema. " 07/01/1984 - "The aim of this study was to evaluate the following methods of postmastectomy lymphedema treatment: pneumatic massage with uniform pressure, pneumatic massage with differentiated pressure, and manual lymphatic massage. " Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 03/01/2006 - "CONCLUSION: LN transplantation is a safe procedure permitting good long-term results, disappearance, or a noteworthy improvement, in postmastectomy lymphedema, especially in the early stages of the disease." 09/01/1994 - "We evaluated the use of transplantation of the greater omentum in the management of chronic lymphedema in 21 patients. " 10/01/1985 - "Experimental autologous lymphatic duct transplantation is technically feasible and therapeutically effective in the treatment of chronic lymphedema of the extremity. " 03/01/2000 - "[Experimental study of lymph node flap transplantation for treatment of lymphedema]" 09/01/2009 - "BACKGROUND: The authors' objective was to test whether the transplantation of an autologous lymph node into a nodal excision site in sheep would restore lymphatic transport function and reduce the magnitude of postsurgical lymphedema. " Order ALL the reference details at left...
3.	Lipectomy (Liposuction) 07/01/2009 - "Although currently there is no single treatment proven effective for lymphedema in every patient, suction-assisted lipectomy has been shown to be effective in some patients. " 07/01/2006 - "CONCLUSIONS: Altrasonic assisted liposuction combined with elastic compression is safe and effective for the treatment of primary limb lymphedema." 01/01/2009 - "Treatment of upper limb lymphedema with combination of liposuction, myocutaneous flap transfer, and lymph-fascia grafting: a preliminary study." 07/01/2009 - "In this article we present a case of lymphedema reduction with suction-assisted lipectomy in a patient with bilateral lower-extremity lymphedema." 07/01/2009 - "Suction-assisted lipectomy offers patients with lower-extremity lymphedema a less invasive, less morbid surgical option compared with traditional excisional techniques. " Order ALL the reference details at left...
4.	Aftercare (After-Treatment) 06/01/2008 - "Absolute volume and percentage of volume of the lymphedema were compared before and after treatment. " 06/01/2007 - "Absolute volume and percentage of volume of lymphedema was compared before and after treatment. " 07/01/2006 - "Mean excess volume of lymphedema was 1067+/-622 ml prior treatment and 663+/-366 ml after treatment (p<0.001), percentage of excess volume of lymphedema was 59+/-34% and 36+/-19%, respectively. " 12/01/2001 - "We studied the effects of the Lymphapress pump (LP; Global Medical Imports, Digby, NS, Canada) retrospectively on 16 children with primary or secondary lymphedema of the upper or lower extremities by measuring the volume and circumference of the limbs before and after treatment. " 09/15/2001 - "RESULTS: At 20 years after treatment, 49% (128 of 263) reported the sensation of lymphedema. " Order ALL the reference details at left...
5.	Lymph Node Excision (Lymph Node Dissection) 03/01/2007 - "In conclusion, this questionnaire survey suggested that leaving the retroperitoneum open after lymphadenectomy is significantly effective in reducing the incidence of leg lymphedema, which impairs patients' quality of life more than expected by physicians." 09/01/2006 - "This surgical modality is effective in preventing lymphedema in lower extremities after intrapelvic para-aortic lymph node dissection." 11/10/2008 - "The aim of this study was to determine the long-term prevalence of lymphedema after SLN biopsy (SLNB) alone and after SLNB followed by axillary lymph node dissection (SLNB/ALND). " 01/01/1980 - "The study of possible drainage pathways for the upper extremity after axillary lymphadenectomy by means of Indian ink injection shows: 1) that the single drainage is through the lateral upper arm bundle, but only if the latter joins the supraclavicular nodes or if its infraclavicular ending remains unremoved; 2) that the lateral bundle occur as either a long or a short type; 3) that with regard to the lymphatic drainage of the skin, areolae, zones and territories can be distinguished; 4) that a long bundle is the more suitable collateral way as collectors of the forearm territory join it; 5) that the most frequent cause of lymphedema is the fact that lymph of the forearm as well as of the dorsomedial upper arm territory can reach the lateral bundle only via the cutaneous plexus, over the lymphatic watersheds." 08/01/2009 - "BACKGROUND: Lymphedema is a common debilitating sequela of lymph node dissection. " Order ALL the reference details at left...

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