Adiponectin, Interleukin-6 and High-sensitivity C-reactive Protein Levels in Overweight/Obese Indian children.

Abstract

OBJECTIVE:

The aim of our study was to assess serum Adiponectin, Interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) levels and their correlation with conventional risk factors for cardiovascular disease and diabetes in overweight/obese Indian children.

METHODS:

Body mass index (BMI), waist circumference, blood pressure, fasting serum adiponectin, IL-6, hsCRP, blood glucose, triglycerides, and total and high density lipoprotein cholesterol were measured in children aged 7-15 years with BMI >85th centile.

RESULTS:

84 overweight/obese children (48 boys) with mean (SD) age 10.2 (1.9) years were enrolled. Mean (SD) adiponectin, hsCRP and median (IQR) IL-6 levels were 6.0 (3.1) µg/mL, 3.4 (2.4) mg/L and 12.7 (5.0-90.0) pg/mL, respectively. Low adiponectin, high hsCRP and high IL-6 were noted in 16.5%, 49.4% and 54.4% participants, respectively. Adiponectin was inversely correlated with waist circumference, and IL-6 positively with BMI and blood glucose.

CONCLUSION:

Inflammatory mediators, hsCRP and IL-6 were elevated in half of the overweight children. Adiponectin and IL-6 correlated well with traditional risk markers.

• Authors: Vandana Jain, Ajay Kumar, Anuja Agarwala, Naval Vikram, Lakshmy Ramakrishnan
• Journal: Indian pediatrics (Indian Pediatr) Vol. 54 Issue 10 Pg. 848-850 (Oct 15 2017) ISSN: 0974-7559 [Electronic] India
• PMID: 28699615 (Publication Type: Journal Article)

Chemical References

• ADIPOQ protein, human
• Adiponectin
• IL6 protein, human
• Interleukin-6
• C-Reactive Protein

Topics

• Adiponectin (blood)
• Adolescent
• C-Reactive Protein (analysis)
• Child
• Cross-Sectional Studies
• Female
• Humans
• Interleukin-6 (blood)
• Male
• Metabolic Syndrome
• Overweight (blood, epidemiology)
• Pediatric Obesity (blood, epidemiology)