Combination of citrus polymethoxyflavones, green tea polyphenols, and Lychee extracts suppresses obesity and hepatic steatosis in high-fat diet induced obese mice.

Abstract

SCOPE:

SlimTrym® is a formulated product composed of citrus polymethoxyflavones (PMFs), green tea extract, and lychee extract. We investigated the effect of dietary SlimTrym® on diet-induced obesity and associated non-alcoholic fatty liver disease (NAFLD) in mice.

METHODS AND RESULTS:

Male C57BL/6 mice were fed a normal diet (ND), high fat diet (HFD) or HFD containing 0.1% or 0.5% SlimTrym® for 16 weeks. Dietary SlimTrym® significantly reduced weight gain and relative perigonadal, retroperitoneal, mesenteric fat weight as well as the size of adipocyte in HFD-fed mice. SlimTrym® supplementation also effectively diminished hepatic steatosis and the serum levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), triacylglycerol (TG), and total cholesterol (TCHO). Down-regulation of peroxisome proliferator-activated receptor (PPAR)γ, sterol regulatory element-binding protein (SREBP)-1, and the activation of AMP-activated protein kinase (AMPK) signaling by SlimTrym® in both adipose tissue and liver may be responsible for the observed anti-obesity effects.

CONCLUSION:

SlimTrym® supplementation potentially diminished diet-induced obesity and hepatic steatosis via regulating AMPK signaling and molecules involved in lipid metabolism.

• Authors: Min-Hsiung Pan, Guliang Yang, Shiming Li, Ming-Yi Li, Mei-Ling Tsai, Jia-Ching Wu, Vladimir Badmaev, Chi-Tang Ho, Ching-Shu Lai
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 61 Issue 11 (11 2017) ISSN: 1613-4133 [Electronic] Germany
• PMID: 28643888 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Anti-Obesity Agents
• Biomarkers
• Flavones
• Plant Extracts
• Polyphenols

Topics

• Adipogenesis
• Animals
• Anti-Obesity Agents (administration & dosage, analysis, chemistry, therapeutic use)
• Biomarkers (blood, metabolism)
• Camellia sinensis (chemistry)
• Citrus (chemistry)
• Diet, High-Fat (adverse effects)
• Dietary Supplements (analysis)
• Ethnopharmacology
• Flavones (administration & dosage, analysis, chemistry, therapeutic use)
• Food Handling
• Fruit (chemistry)
• Litchi (chemistry)
• Male
• Methylation
• Mice, Inbred C57BL
• Non-alcoholic Fatty Liver Disease (blood, etiology, metabolism, prevention & control)
• Obesity (blood, etiology, metabolism, prevention & control)
• Oxidation-Reduction
• Plant Extracts (administration & dosage, therapeutic use)
• Plant Leaves (chemistry)
• Polyphenols (administration & dosage, analysis, chemistry, therapeutic use)
• Taiwan