Visual Evaluation of Medial Temporal Lobe Atrophy as a Clinical Marker of Conversion from Mild Cognitive Impairment to Dementia and for Predicting Progression in Patients with Mild Cognitive Impairment and Mild Alzheimer's Disease.

Abstract

BACKGROUND/AIMS:

To evaluate whether visual assessment of medial temporal lobe atrophy (vaMTA) can predict 2-year conversion from mild cognitive impairment (MCI) to dementia and progression of MCI and Alzheimer's disease dementia as measured by the Clinical Dementia Rating Scale Sum of Boxes score (CDR-SB).

METHODS:

vaMTA was performed in 94 patients with MCI according to the Winblad criteria and in 124 patients with AD according to ICD-10 and NINCDS-ADRDA criteria. Demographic data, the Consortium to Establish a Registry for Alzheimer's Disease 10-word delayed recall, APOE ɛ4 status, Cornell Scale for Depression in Dementia, and comorbid hypertension were used as covariates.

RESULTS:

vaMTA was associated with MCI conversion in an unadjusted model but not in an adjusted model (p = 0.075), where delayed recall and APOE ɛ4 status were significant predictors. With CDR-SB change as the outcome, an interaction between vaMTA and diagnosis was found, but in the adjusted model only delayed recall and age were significant predictors. For vaMTA below 2, the association between vaMTA and CDR-SB change differed between diagnostic groups. Similar results were found based on a trajectory analysis.

CONCLUSION:

In adjusted models, memory function, APOE ɛ4 status and age were significant predictors of disease progression, not vaMTA. The association between vaMTA and CDR-SB change was different in patients with MCI and Alzheimer's disease dementia.

• Authors: Karin Persson, Maria Lage Barca, Rannveig Sakshaug Eldholm, Lena Cavallin, Jūratė Šaltytė Benth, Geir Selbæk, Anne Brækhus, Ingvild Saltvedt, Knut Engedal
• Journal: Dementia and geriatric cognitive disorders (Dement Geriatr Cogn Disord) Vol. 44 Issue 1-2 Pg. 12-24 ( 2017) ISSN: 1421-9824 [Electronic] Switzerland
• PMID: 28614836 (Publication Type: Journal Article)
• Copyright: © 2017 S. Karger AG, Basel.

Chemical References

• Apolipoprotein E4
• Biomarkers

Topics

• Age Factors
• Aged
• Aged, 80 and over
• Alzheimer Disease (diagnosis, psychology)
• Apolipoprotein E4 (analysis)
• Atrophy
• Biomarkers
• Cognitive Dysfunction (diagnosis, psychology)
• Disease Progression
• Female
• Humans
• Male
• Mental Status and Dementia Tests
• Neuropsychological Tests
• Predictive Value of Tests
• Temporal Lobe (diagnostic imaging, pathology)