Abstract | PURPOSE: To evaluate the relationship between aortic inflammation as assessed by 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) and features of plaque vulnerability as assessed by frequency domain-optical coherence tomography (FD-OCT). METHODS: We enrolled 30 consecutive non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. All patients underwent three-vessel OCT before intervention and 18F-FDG-PET before discharge. Univariable and C-reactive protein (CRP)-adjusted linear regression analyses were performed between features of vulnerability [namely: lipid-rich plaques with and without macrophages and thin cap fibroatheromas (TCFA)] and 18F-FDG uptake in both ascending (AA) and descending aorta (DA) [measured either as averaged mean and maximum target-to-blood ratio (TBR) or as active slices (TBRmax ≥ 1.6)]. RESULTS: Mean age was 62 years, and 26 patients were male. On univariable linear regression analysis TBRmean and TBRmax in DA was associated with the number of lipid-rich plaques (β = 4.22; 95%CI 0.05-8.39; p = 0.047 and β = 3.72; 95%CI 1.14-6.30; p = 0.006, respectively). TBRmax in DA was also associated with the number of lipid-rich plaques containing macrophages (β = 2.40; 95%CI 0.07-4.72; p = 0.044). A significant CRP adjusted linear association between the TBRmax in DA and the number of lipid-rich plaques was observed (CRP-adjusted β = 3.58; 95%CI -0.91-6.25; p = 0.01). TBRmax in DA showed a trend towards significant CRP-adjusted association with number of lipid-rich plaques with macrophages (CRP-adjusted β = 2.30; 95%CI -0.11-4.71; p = 0.06). We also observed a CRP-adjusted (β = 2.34; 95%CI 0.22-4.47; p = 0.031) linear association between the number of active slices in DA and the number of lipid-rich plaques. No relation was found between FDG uptake in the aorta and the number of TCFAs. CONCLUSIONS: In patients with first NSTEACS, 18F-FDG uptake in DA is correlated with the number of OCT detected lipid-rich plaques with or without macrophages. This association may be independent from CRP values.
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Authors | Nevio Taglieri, Cristina Nanni, Gabriele Ghetti, Rachele Bonfiglioli, Francesco Saia, Maria Letizia Bacchi Reggiani, Giacomo Maria Lima, Valeria Marco, Francesco Prati, Stefano Fanti, Claudio Rapezzi |
Journal | European journal of nuclear medicine and molecular imaging
(Eur J Nucl Med Mol Imaging)
Vol. 44
Issue 11
Pg. 1878-1887
(Oct 2017)
ISSN: 1619-7089 [Electronic] Germany |
PMID | 28584972
(Publication Type: Evaluation Study, Journal Article)
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Chemical References |
- Radiopharmaceuticals
- Fluorodeoxyglucose F18
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Topics |
- Acute Coronary Syndrome
(diagnostic imaging, surgery)
- Adult
- Aorta, Thoracic
(diagnostic imaging, pathology)
- Coronary Angiography
(methods, standards)
- Female
- Fluorodeoxyglucose F18
- Humans
- Male
- Middle Aged
- Percutaneous Coronary Intervention
- Plaque, Atherosclerotic
(diagnostic imaging)
- Positron-Emission Tomography
(methods, standards)
- Radiopharmaceuticals
- Tomography, Optical Coherence
(methods, standards)
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