The soluble transcobalamin receptor (sCD320) in relation to Alzheimer's disease and cognitive scores.

Abstract

The soluble transcobalamin receptor (sCD320) is present in cerebrospinal fluid and correlates with the dementia-related biomarkers phospho-tau and total-tau. Here we present data on the relation of sCD320 to Alzheimer's disease and scores of cognitive tests. Lumbar cerebrospinal fluid samples from 42 pathologically-confirmed cases of Alzheimer's disease and 25 non-demented controls were analyzed for sCD320 employing an in-house ELISA. The participants' cognitive functions were tested using the Cambridge Cognition Examination (CAMCOG) and the Mini-Mental State Examination (MMSE). There was no significant difference in the median CSF sCD320 concentration between patients and controls. The median (2.5-97.5 percentiles) sCD320 for all participants (n = 67) was 15 (3-29) pmol/L. We observed a non-linear correlation between sCD320 and cognitive scores. Spearman's correlation between sCD320 and total CAMCOG scores was 0.627 (n = 16, p = .009) for CAMCOG scores ≤27, and -0.293 (n = 39, p = .071) for CAMCOG scores ≥68. Spearman's correlation between sCD320 and both the low (≤9) and high (≥16) total MMSE scores was 0.274, -0.363 (n = 18, 44), p = .272, .016, respectively. In conclusion, sCD320 cannot be employed as a biomarker for differentiating Alzheimer dementia patients from controls. Further studies are warranted to explore the non-linear correlations between sCD320 and scores of cognitive function.

• Authors: Omar Abuyaman, Marc Combrinck, A David Smith, Ebba Nexo
• Journal: Scandinavian journal of clinical and laboratory investigation (Scand J Clin Lab Invest) Vol. 77 Issue 5 Pg. 332-337 (Sep 2017) ISSN: 1502-7686 [Electronic] England
• PMID: 28486088 (Publication Type: Journal Article)

Chemical References

• Antigens, CD
• Biomarkers
• CD320 protein, human
• Receptors, Cell Surface
• Vitamin B 12

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (cerebrospinal fluid, diagnosis, genetics, physiopathology)
• Antigens, CD (cerebrospinal fluid, genetics)
• Biomarkers (cerebrospinal fluid)
• Case-Control Studies
• Cognition (physiology)
• Cognitive Dysfunction (cerebrospinal fluid, diagnosis, genetics, physiopathology)
• Humans
• Intelligence Tests
• Middle Aged
• Receptors, Cell Surface
• Solubility
• Statistics, Nonparametric
• Vitamin B 12 (metabolism)