Prognostic significance of erythrocyte protein band 4.1-like5 expression in upper urinary tract urothelial carcinoma.

Abstract

OBJECTIVES:

The erythrocyte protein band 4.1-like5 (EPB4.1L5) regulates E-cadherin in cancer invasion and metastasis inducing epithelial-to-mesenchymal transition. This study aimed to investigate the biological significance of EPB4.1L5 in upper urinary tract urothelial carcinoma (UTUC).

METHODS:

Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues.

RESULTS:

The median follow-up period was 62.2 months (interquartile range = 77.0). The score of EPB4.1L5 significantly correlated with tumor grade, pathological T stage, and lymphovascular invasion (all P<0.001). The 5-year Kaplan-Meier recurrence-free survival and cancer-specific survival rates were 54.1% and 59.5% in patients with high EPB4.1L5 expression, compared with 81.6% and 87.2%, (all P<0.001) in their counterparts. Multivariate analyses revealed that high expression of EPB4.1L5 was one of the independent prognostic factors for tumor recurrence (P = 0.022, HR = 2.40) and cancer-specific survival (P = 0.015, HR = 2.94).

CONCLUSION:

High EPB4.1L5 expression was related to worse clinical outcome in patients with UTUC. These results indicated that EPB4.1L5 could provide prognostic information in patients with UTUC regarding epithelial-to-mesenchymal transition.

• Authors: Tatsuaki Daimon, Takeo Kosaka, Eiji Kikuchi, Shuji Mikami, Yasumasa Miyazaki, Ari Hashimoto, Shigeru Hashimoto, Ryuichi Mizuno, Akira Miyajima, Yasunori Okada, Hisataka Sabe, Mototsugu Oya
• Journal: Urologic oncology (Urol Oncol) Vol. 35 Issue 9 Pg. 543.e17-543.e24 (09 2017) ISSN: 1873-2496 [Electronic] United States
• PMID: 28483476 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2017 Elsevier Inc. All rights reserved.

Chemical References

• Cytoskeletal Proteins
• Membrane Proteins
• erythrocyte membrane band 4.1 protein

Topics

• Adult
• Aged
• Aged, 80 and over
• Cytoskeletal Proteins (metabolism)
• Epithelial-Mesenchymal Transition (genetics)
• Female
• Humans
• Male
• Membrane Proteins (metabolism)
• Middle Aged
• Prognosis
• Retrospective Studies
• Survival Analysis
• Urologic Neoplasms (genetics, mortality, pathology)