Abstract | CONTEXT: OBJECTIVE: - To aid pathologists with recent recommendations for diagnoses of common neuropathologies in older persons, particularly hippocampal sclerosis, and highlight the recent shift in diagnostic terminology from HS-aging to cerebral age-related TDP-43 with sclerosis (CARTS). DATA SOURCES: - Peer-reviewed literature and 5 autopsy examples that illustrate common age-related neuropathologies, including CARTS, and emphasize the importance of distinguishing CARTS from late-onset frontotemporal lobar degeneration with TDP-43 pathology and from advanced Alzheimer disease with TDP-43 pathology. CONCLUSIONS: - In advanced old age, the substrates of cognitive impairment are often multifactorial. This article demonstrates common and frequently comorbid neuropathologic substrates of cognitive impairment in the older population, including CARTS, to aid those practicing in this area of pathology.
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Authors | Matthew D Cykowski, Suzanne Z Powell, Paul E Schulz, Hidehiro Takei, Andreana L Rivera, Robert E Jackson, Gustavo Roman, Gregory A Jicha, Peter T Nelson |
Journal | Archives of pathology & laboratory medicine
(Arch Pathol Lab Med)
Vol. 141
Issue 8
Pg. 1113-1126
(Aug 2017)
ISSN: 1543-2165 [Electronic] United States |
PMID | 28467211
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- DNA-Binding Proteins
- TARDBP protein, human
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Topics |
- Aged
- Aged, 80 and over
- Brain Diseases
(complications, pathology)
- DNA-Binding Proteins
(metabolism)
- Dementia
(etiology)
- Female
- Hippocampus
(pathology)
- Humans
- Male
- Sclerosis
(complications, pathology)
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