C-X-C motif
chemokine 9 (CXCL9), CXCL10, and CXCL11 are produced in response to
interferon-γ (IFN-γ) and trigger
inflammation with the accumulation of activated lymphocytes. It appears that these
chemokines could play a role in the pathogenesis of
adult-onset Still's disease (AOSD). Therefore, we investigated the associations between the levels of these
chemokine and clinical manifestations in patients with active AOSD. Serum levels of IFN-γ, CXCL9, CXCL10 and CXCL11 were determined using
enzyme-linked
immunosorbent assays. IFN-γ levels were higher in AOSD patients than in
rheumatoid arthritis (RA) patients (p = 0.001) or healthy controls (HCs) (p = 0.032). AOSD patients also exhibited higher levels of CXCL9, CXCL10, and CXCL11 compared with RA patients (p < 0.001) and HCs (p < 0.001). In follow-up AOSD patients
after treatment with
corticosteroid, the levels of CXCL9, CXCL10 and CXCL11 fell significantly, whereas IFN-γ levels were not significantly different. On immunohistochemistry, the percentage of CXCL10-positive inflammatory cells was higher in skin biopsy samples from AOSD patients than in those from normal control (p = 0.012),
eczema (p = 0.019), and
psoriasis (p = 0.009) groups. Levels of the IFN-γ-induced
chemokines, CXCL9, CXCL10 and CXCL11, were elevated and correlated with several disease activity markers. These
interferon-γ-induced
chemokines may contribute to inflammatory responses and
skin manifestations in AOSD.