Adult-Onset Still's Disease

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171 relevant articles (17 outcomes, 3 trials/studies) found for this Disease

Description: Systemic-onset rheumatoid arthritis in adults. It differs from classical rheumatoid arthritis in that it is more often marked by acute febrile onset, and generalized lymphadenopathy and hepatosplenomegaly are more prominent.

Also Known As:

Still's Disease, Adult-Onset; Adult-Onset Still Disease; Still Disease, Adult-Onset; Adult Onset Still Disease; Adult Onset Still's Disease; Adult-Onset Stills Disease; Still Disease, Adult Onset; Still's Disease, Adult Onset; Stills Disease, Adult-Onset

Relationship Network

Disease Context: Research Results

Musculoskeletal Diseases: 87

Rheumatic Diseases: 5000

Rheumatoid Arthritis: 28802

Adult-Onset Still's Disease: 171

Joint Diseases: 1574

Arthritis: 15067

Rheumatoid Arthritis: 28802

Adult-Onset Still's Disease: 171

Skin and Connective Tissue Diseases

Connective Tissue Diseases: 1692

Rheumatic Diseases: 5000

Rheumatoid Arthritis: 28802

Adult-Onset Still's Disease: 171

Immune System Diseases: 1319

Autoimmune Diseases: 12462

Rheumatoid Arthritis: 28802

Adult-Onset Still's Disease: 171

Related Diseases

1.	Juvenile Rheumatoid Arthritis (Juvenile Idiopathic Arthritis)
2.	Myocarditis (Carditis)
3.	Hemophagocytic Lymphohistiocytosis (Hemophagocytic Syndrome)
4.	Syndrome
5.	Polymyositis

Experts

1.	Fautrel, B: 3 articles (03/2008 - 05/2000)
2.	Lan, Joung-Liang: 3 articles (12/2007 - 06/2005)
3.	Lin, Fang-Ju: 3 articles (12/2007 - 06/2005)
4.	Hsieh, Tsu-Yi: 3 articles (12/2007 - 06/2005)
5.	Chen, Der-Yuan: 3 articles (12/2007 - 06/2005)
6.	Yoo, Dae-Hyun: 3 articles (07/2007 - 02/2004)
7.	Hara, M: 3 articles (08/2006 - 07/2001)
8.	Kamatani, N: 3 articles (08/2006 - 07/2001)
9.	Kawaguchi, Y: 3 articles (08/2006 - 07/2001)
10.	Le Moël, G: 3 articles (05/2004 - 05/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Adult-Onset Still's Disease:

1.	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 05/01/2008 - "Effective treatment of steroid refractory adult-onset Still's disease with anakinra." 06/01/2007 - "Anakinra treatment in patients with adult-onset Still's disease is fast, effective, safe and steroid sparing: experience from an uncontrolled trial." 12/01/2007 - "Anakinra in patients with treatment-resistant adult-onset Still's disease: four case reports with serial cytokine measurements and a review of the literature." 09/01/2007 - "Anakinra (Kineret), a recombinant IL1 Receptor Antagonist (IL 1 RA) was therefore recently proposed in adult onset Still's disease with great efficacy. " 06/01/2005 - "Rapid responses to anakinra in patients with refractory adult-onset Still's disease." Order ALL the reference details at left...
2.	TNFR-Fc fusion protein (etanercept)FDA Link 02/01/2006 - "Prolonged remission in adult-onset Still's disease with etanercept." 09/01/2002 - "Adult onset Still's disease: response to Enbrel." 11/01/2008 - "Etanercept as a rescue agent in patient with adult onset Still's disease complicated with congestive heart failure." 05/01/2005 - "[Application of etanercept in treatment of juvenile idiopathic arthritis and adult onset still disease]" 08/01/2001 - "Worsening of macrophage activation syndrome in a patient with adult onset Still's disease after initiation of etanercept therapy." Order ALL the reference details at left...
3.	infliximab (Remicade)FDA Link 01/01/2005 - "Prolonged efficacy of infliximab for refractory adult-onset Still's disease." 02/01/2004 - "Successful treatment of refractory adult-onset Still's disease with infliximab. " 10/01/2003 - "Infliximab in a case of early adult-onset Still's disease." 01/01/2002 - "A case of adult onset Still's disease treated with infliximab." 06/01/2006 - "Administration of infliximab was discontinued for treatment of adult onset Still's disease, and steroid levels were reduced following double-membrane filtration plasma exchange. " Order ALL the reference details at left...
4.	Immunoglobulins (Immunoglobulin)IBA 02/01/2009 - "High levels of immunoglobulins have been observed in patients with the active stage of adult onset Still's disease (AOSD), and high-dose intravenous immunoglobulin treatment has decreased the disease activity of AOSD. " 01/01/1999 - "Precise mechanisms of action of intravenous immunoglobulin in adult onset Still's disease remain unclear. " 11/01/2007 - "Comment on: Adult-onset Still's disease and myocarditis: successful treatment with intravenous immunoglobulin and maintenance of remission with etanercept." 06/01/2007 - "Adult-onset Still's disease and myocarditis: successful treatment with intravenous immunoglobulin and maintenance of remission with etanercept." Order ALL the reference details at left...
5.	Methotrexate (Mexate)FDA LinkGeneric 02/01/2008 - "Steroid-resistant adult-onset Still's disease which showed a quick response to methotrexate." 01/01/2007 - "Adult-onset Still's disease in a patient over 80 years old successfully treated with low-dose methotrexate therapy." 02/01/1997 - "OBJECTIVE: To evaluate methotrexate treatment in patients with active adult onset Still's disease (AOSD). " 02/01/1997 - "Methotrexate treatment in patients with adult onset Still's disease--retrospective study of 13 Japanese cases." 10/03/1992 - "A possible role of methotrexate in the management of adult onset Still's disease is suggested." Order ALL the reference details at left...
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2009 - "Cyclosporin A treatment for Japanese patients with severe adult-onset Still's disease." 11/01/2002 - "After cyclosporine was given, all the above symptoms associated with adult-onset Still's disease disappeared. " 08/01/1997 - "OBJECTIVE: To determine whether cyclosporin A (CyA) is a useful option in the treatment of adult onset Still's disease (ASD). " 08/01/1997 - "Cyclosporin A in the treatment of adult onset Still's disease." 12/03/2005 - "CASE: The authors report a case of life-threatening adult-onset Still disease with hemophagocytic syndrome, which improved dramatically with cyclosporin A. " Order ALL the reference details at left...
7.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 11/01/2006 - "Decrease of proteinuria in a patient with adult-onset Still's disease and glomerulonephritis after anti-TNFalpha therapy." 09/01/2005 - "Adalimumab (anti-TNF-alpha) therapy to improve the clinical course of adult-onset Still's disease: the first case report." 08/15/1998 - "TNFalpha and response of treatment-resistant adult-onset Still's disease to thalidomide." 05/01/2009 - "TNFalpha blockers might be an option in refractory ANCA-associated vasculitis, sarcoïdosis, adult onset Still disease, Behçet disease, AA amyloïdosis and TRAPS. " 08/01/2001 - "We report the case of a young woman with adult-onset Still's disease (AOSD), complicated by an Epstein-Barr virus infection and subsequent MAS, whose course worsened after administration of the soluble tumor necrosis factor-alpha receptor, etanercept. " Order ALL the reference details at left...
8.	tocilizumabIBA 05/01/2005 - "Clinical efficacy of tocilizumab in RA, soJIA, adult-onset Still's disease or CD patients has been discussed in this review. " 01/01/2009 - "A case report of a patient with refractory adult-onset Still's disease who was successfully treated with tocilizumab over 6 years." 01/01/2009 - "Tocilizumab for multirefractory adult-onset Still's disease." 05/01/2009 - "Tocilizumab is also a promising therapeutic option for other rheumatic diseases such as systemic-onset juvenile idiopathic arthritis, adult-onset Still's disease, and Takayasu arteritis. " 04/01/2009 - "Glucocorticoid and cyclosporine refractory adult onset Still's disease successfully treated with tocilizumab." Order ALL the reference details at left...
9.	InterleukinsIBA 01/01/2007 - "We report on an 83-year-old Japanese woman with adult-onset Still's disease (AOSD), with marked hypercytokinemia (serum levels of ferritin (Fer) and interleukin (IL)-18 were markedly high). " 09/01/2006 - "Tocilizumab (namely MRA), a humanized anti-interleukin (IL)-6 receptor monoclonal antibody, is under development by Roche for the treatment of inflammatory autoimmune diseases such as rheumatoid arthritis (RA), systemic onset juvenile idiopathic arthritis (JIA), adult-onset Still's disease, Castleman's disease and Crohn's disease. " 12/01/2007 - "OBJECTIVE: To determine the efficacy of the interleukin (IL)-1-receptor antagonist (IL-1RA) anakinra in patients with adult-onset Still's disease (AOSD) refractory to standard treatments such as glucocorticosteroids (GC), immunosuppressive drugs, and tumor necrosis factor (TNF)-antagonists; to verify disease remission objectively by serial cytokine measurements; and to review the current literature on anakinra for this indication. " 06/01/2007 - "Proinflammatory cytokines such as interleukin (IL)-1, IL-6, and IL-18, interferon-gamma, tumor necrosis factor, and macrophage colony-stimulating factor are elevated in patients with adult-onset Still's disease and are thought to have a major role in the pathogenesis of the disease. " Order ALL the reference details at left...
10.	Adrenal Cortex Hormones (Corticosteroids)IBA 12/01/2009 - "The diagnosis of adult-onset Still's disease was established after the reappearance of symptoms after transplantation, and high doses of corticosteroids were used to control disease activity. " 05/01/1989 - "MTX and corticosteroids in combination may be indicated for the treatment of adult onset Still's disease when PM and erosive arthritis occur." 05/01/1989 - "We describe a patient with adult onset Still's disease, polymyositis (PM) and rhabdomyolysis successfully treated with methotrexate (MTX) and corticosteroids. " 05/01/1989 - "Coexistence of adult onset Still's disease and polymyositis with rhabdomyolysis successfully treated with methotrexate and corticosteroids." 02/01/2004 - "In this prospective, non-comparative case series, four patients with severe and highly active adult-onset Still's disease (AOSD), refractory to high doses of corticosteroids (which had been combined with methotrexate in three of them) and methotrexate were treated with infliximab (initial dose 3-5 mg/kg, continuing at intervals depending on the patient's individual disease activity). " Order ALL the reference details at left...

Therapies and Procedures

1.	Plasmapheresis 10/10/1993 - "[Marked efficacy of double filtration plasmapheresis in 3 cases of adult-onset Still's disease]" 07/01/2006 - "Double-filtration plasmapheresis for resolution of corticosteroid resistant adult onset Still's disease." Order ALL the reference details at left...
2.	Peripheral Blood Stem Cell Transplantation (Peripheral Stem Cell Transplantation) 06/01/2000 - "Prolonged remission state of refractory adult onset Still's disease following CD34-selected autologous peripheral blood stem cell transplantation." Order ALL the reference details at left...
3.	Plasma Exchange 01/01/2008 - "Successful treatment with plasma exchange in adult-onset Still's disease with hyper-IL-18-naemia and hyperallergic state." 06/01/2006 - "Administration of infliximab was discontinued for treatment of adult onset Still's disease, and steroid levels were reduced following double-membrane filtration plasma exchange. " Order ALL the reference details at left...
4.	Liver Transplantation 12/01/2009 - "[Adult-onset Still's disease with liver failure requiring liver transplantation.]" Order ALL the reference details at left...
5.	X-Ray Film 07/01/2006 - "We describe a 63-year-old man who, while under treatment as an outpatient for adult onset Still's disease (AOSD), developed edema of the extremities and mediastinal tumor was observed on a chest X-ray film and a chest CT scan. " Order ALL the reference details at left...

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