Abstract | PURPOSE: To assess pupil diameter before and after femtosecond laser-assisted capsulotomy in patients who were pretreated with a short-term topical nonsteroidal anti-inflammatory drug ( NSAID) ( ketorolac) versus those without pretreatment. METHODS: This prospective, randomized, observational case series included consecutive patients scheduled to undergo cataract extraction using the Catalys femtosecond laser platform (Abbott Medical Optics, Inc., Santa Ana, CA) to perform only capsulotomies. The same protocol for preoperative medical mydriasis was used for all patients, whereas pupil diameter was assessed using a surgical ruler immediately before and 3 minutes after femtosecond laser-assisted capsulotomy. The patients were divided into two groups: one received short-term topical ketorolac preoperatively and the other did not receive NSAID pretreatment (control). RESULTS: A total of 42 eyes of 42 patients (1 eye per patient) were included in the study. Mean pupillary miosis was 0.79 ± 1.08 and 1.57 ± 1.19 mm for the ketorolac and control groups, respectively. There was a statistically significant decrease in pupil diameter for both groups individually (P < .05). There was also a statistically significant difference between the two groups (P < .05) with the induced miosis in the eyes that did not receive topical NSAIDs prior to cataract extraction being twofold greater when compared with the miosis of the eyes that received ketorolac pretreatment. CONCLUSIONS:
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Authors | Vasilios F Diakonis, Georgios A Kontadakis, Apostolos G Anagnostopoulos, Nilufer Yesilirmak, Daniel P Waren, Florence Cabot, Sonia H Yoo, Kendall E Donaldson |
Journal | Journal of refractive surgery (Thorofare, N.J. : 1995)
(J Refract Surg)
Vol. 33
Issue 4
Pg. 230-234
(Apr 01 2017)
ISSN: 1081-597X [Print] United States |
PMID | 28407162
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright 2017, SLACK Incorporated. |
Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Ketorolac
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Topics |
- Administration, Topical
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage)
- Dose-Response Relationship, Drug
- Female
- Follow-Up Studies
- Humans
- Intraoperative Complications
(prevention & control)
- Ketorolac
(administration & dosage)
- Lasers, Excimer
(therapeutic use)
- Male
- Middle Aged
- Posterior Capsulotomy
(methods)
- Postoperative Complications
(prevention & control)
- Preoperative Care
(methods)
- Prospective Studies
- Pupil
(drug effects)
- Time Factors
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