Abstract | BACKGROUND: OBJECTIVE: This prospective study examined the relationships of aging, persist overweight and plasma fatty acids with arterial stiffening over 3 years. METHODS: We divided a cohort of 179 healthy, nonhypertensive subjects (aged ≥50 years) into 2 groups: a normal-weight group (18.5 kg/m2 ≤ body mass index [BMI] < 25 kg/m2, n = 103) and an overweight group (25 kg/m2 ≤ BMI< 30 kg/m2, n = 76). Brachial-ankle pulse wave velocity (ba-PWV) and plasma fatty acids were measured at baseline and after 3 years. RESULTS: After 3 years, the overweight group showed greater increases in systolic and diastolic blood pressure, insulin, homeostasis model assessment- Insulin resistance index and ba-PWV values (P = .009) than the normal-weight group. In addition, greater reductions in eicosapentaenoic acid (C20:3, n-3, EPA; P = .009) and the EPA/ arachidonic acid (C20:4, n-6, AA) ratio (P = .001) were found in the overweight group. Multivariate analyses revealed that changes in (Δ) ba-PWV were significantly and positively associated with baseline BMI values and ΔAA/ linoleic acid ratios (C18:2, n-6, LA) and negatively associated with ΔEPA/AA ratios. In a subanalysis using baseline BMI values, Δba-PWV correlated strongly and negatively with ΔEPA/AA ratios (r = -0.595, P < .001) and positively with ΔAA/LA ratios (r = 0.455, P < .001) in the overweight group. CONCLUSION: This study suggests that the persistence of overweight over 3 years in subjects ≥50 years old is associated with faster arterial stiffening than is observed in normal-weight subjects and that this stiffening is independently associated with increases in AA/LA and decreases in EPA/AA ratios.
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Authors | Seung Han Baek, Minkyung Kim, Minjoo Kim, Hye Jin Yoo, Ayoung Lee, Minjae Ji, Min Song, Jong Ho Lee |
Journal | Journal of clinical lipidology
(J Clin Lipidol)
2017 Jan - Feb
Vol. 11
Issue 1
Pg. 185-194.e2
ISSN: 1933-2874 [Print] United States |
PMID | 28391885
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 National Lipid Association. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Aging
(blood, physiology)
- Cohort Studies
- Fatty Acids, Unsaturated
(blood)
- Female
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Overweight
(blood, physiopathology)
- Prospective Studies
- Pulse Wave Analysis
- Risk Factors
- Vascular Stiffness
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