Abstract | BACKGROUND: METHODS: In 103 consecutive patients with the first anterior STEMI ox-LDL and hs-CRP were measured before pPCI, on day 2 and day 7 after pPCI. RESULTS: Patients were classified into: non-diabetics, pre-diabetics and diabetics. In each group the maximal ox-LDL concentration was found on admission, decreased on day 2 and reached the lowest values on day 7 (p<0.001). Diabetics had the highest ox-LDL concentrations compared to pre-diabetics and non-diabetics (on admission: p=0.028, on day 2: p=0.056, on day 7: p=0.004). hs-CRP concentration rose from admission, reached its peak on day 2 and decreased on day 7, in each group (p<0.001). Significant differences in hs-CRP concentrations were found between non-diabetics and pre-diabetics on admission (p=0.018) and day 2 (p=0.026). In a multivariate analysis DM was an independent determinant of high ox-LDL concentrations. Both ox-LDL and hs-CRP significantly correlated with Killip class, left ventricular ejection fraction, NT-proBNP and peak troponin I. CONCLUSIONS: In patients with the first STEMI treated by pPCI there were significant differences in ox-LDL and hs-CRP concentrations between non-diabetics, pre-diabetics and diabetics. Ox-LDL and hs-CRP concentrations were related to heart failure parameters.
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Authors | Danijela Trifunović, Sanja Stanković, Jelena Marinković, Marko Banović, Nina Đukanović, Olga Vasović, Bosiljka Vujisić-Tešić, Milan Petrović, Jelena Stepanović, Ana Đorđević-Dikić, Branko Beleslin, Ivana Nedeljković, Milorad Tešić, Miodrag Ostojić |
Journal | Journal of medical biochemistry
(J Med Biochem)
Vol. 34
Issue 2
Pg. 160-169
(Apr 2015)
ISSN: 1452-8258 [Print] Serbia |
PMID | 28356828
(Publication Type: Journal Article)
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