2D Shear Wave Elastography of Liver in Patients with Primary Extrahepatic Portal Vein Obstruction.

Abstract

AIMS:

To evaluate liver stiffness (LS) in patients of primary extrahepatic portal vein obstruction (EHPVO) using 2D shear wave elastography (SWE) and compare it with healthy volunteers.

METHODS:

Fifty patients (mean age: 22.4 years) of EHPVO and 25 healthy volunteers were included in the study. Liver function tests and viral markers were done in both groups and endoscopy in EHPVO group, followed by ultrasonography and SWE of liver. Liver elastography was done with patients/volunteers in supine position through right intercostal space. The LS for right lobe of liver was recorded in kilopascals. Three such measurements were taken and the mean of both groups were compared. The variables were also correlated with mean LS using Pearson's correlation coefficient in EHPVO group.

RESULTS:

There was no significant difference in the mean LS in patients of EHPVO (5.96 kPa) and healthy volunteers (5.47 kPa) (P = 0.093). There was no significant correlation between LS with duration of symptoms, hematemesis, esophageal varices, total bilirubin, serum alkaline phosphatase and aspartate aminotranferase levels in EHPVO group.

CONCLUSION:

SWE of liver may be used as a simple additional tool in the diagnosis of patients of EHPVO who show LS values similar to normal liver.

• Authors: Kumble S Madhusudhan, Raju Sharma, Ragini Kilambi, Sudhin Shylendran, Shalimar, Peush Sahni, Arun K Gupta
• Journal: Journal of clinical and experimental hepatology (J Clin Exp Hepatol) Vol. 7 Issue 1 Pg. 23-27 (Mar 2017) ISSN: 0973-6883 [Print] India
• PMID: 28348467 (Publication Type: Journal Article)