The miR-30 family: Versatile players in breast cancer.

Abstract

The microRNA family, miR-30, plays diverse roles in regulating key aspects of neoplastic transformation, metastasis, and clinical outcomes in different types of tumors. Accumulating evidence proves that miR-30 family is pivotal in the breast cancer development by controlling critical signaling pathways and relevant oncogenes. Here, we review the roles of miR-30 family members in the tumorigenesis, metastasis, and drug resistance of breast cancer, and their application to predict the prognosis of breast cancer patients. We think miR-30 family members would be promising biomarkers for breast cancer and may bring a novel insight in molecular targeted therapy of breast cancer.

• Authors: Su-Jin Yang, Su-Yu Yang, Dan-Dan Wang, Xiu Chen, Hong-Yu Shen, Xiao-Hui Zhang, Shan-Liang Zhong, Jin-Hai Tang, Jian-Hua Zhao
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 39 Issue 3 Pg. 1010428317692204 (Mar 2017) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 28347244 (Publication Type: Journal Article, Review)

Chemical References

• Biomarkers, Tumor
• MIRN30b microRNA, human
• MicroRNAs

Topics

• Biomarkers, Tumor (genetics, metabolism)
• Breast Neoplasms (genetics, metabolism, pathology)
• Carcinogenesis (genetics, metabolism)
• Drug Resistance, Neoplasm
• Female
• Humans
• MicroRNAs (genetics, metabolism)
• Neoplasm Metastasis
• Signal Transduction (genetics)