Abstract | SCOPE: METHODS AND RESULTS: A total of 642 school-aged children in Jinan, China, were selected by stratified cluster nested sampling. Anthropometric and biochemical measurements, as well as genotyping of tag single nucleotide polymorphisms (SNPs) of SREBF1, were performed in this sample. Nutritional intake assessments were completed using a 24-h dietary recall for three consecutive days. Multilevel mixed-effects linear regression was used to test interactions between SREBF1 SNPs and cholesterol intakes for obesity. Results showed that SREBF1 rs2236513/rs2297508/rs4925119 strongly modulated the relationship between cholesterol intake and serum LDL-cholesterol/total cholesterol levels (p < 0.001). While SREBF1 rs4925118 modulated the relationship between cholesterol intake and homeostasis model assessment of insulin resistance related characteristics (p < 0.05). CONCLUSION: These results suggest that cholesterol intake recommendation may need to account for SREBF1 variation.
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Authors | Shixiu Zhang, Xinying Lin, Henry Lynn, Guifa Xu, Jun Li, Changfeng Zhao, Mingmei Li |
Journal | Molecular nutrition & food research
(Mol Nutr Food Res)
Vol. 61
Issue 9
(09 2017)
ISSN: 1613-4133 [Electronic] Germany |
PMID | 28333398
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Cholesterol, Dietary
- SREBF1 protein, human
- Sterol Regulatory Element Binding Protein 1
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Topics |
- Child
- Cholesterol, Dietary
(pharmacology)
- Cross-Sectional Studies
- Female
- Genotype
- Humans
- Insulin Resistance
- Male
- Obesity
(metabolism)
- Polymorphism, Single Nucleotide
- Sterol Regulatory Element Binding Protein 1
(genetics)
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