New-onset hepatitis C virus-associated glomerulonephritis following sustained virologic response with direct-acting antiviral therapy
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Abstract

Glomerulonephritis (GN) is an important extra-hepatic manifestation of infection with hepatitis C virus (HCV). HCV-associated GN occurs due to HCV-induced lymphoproliferation, leading to the generation of pathogenic immune complexes, including complexes containing cryoglobulins. The management of HCV-associated extra-hepatic disease is focused on viral eradication, with direct-acting antiviral agents leading to high rates of sustained virologic remission. There have been a few reports of relapsing cryoglobulinemic vasculitis after sustained virologic remission was achieved with interferon-based therapies. This report presents two cases of new-onset HCV-associated GN that occurred after sustained virologic response was achieved with direct-acting antiviral (DAA) therapy.
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• Authors: Muriel Ghosn, Matthew B Palmer, Catherine E Najem, Danny Haddad, Peter A Merkel, Jonathan J Hogan
• Journal: Clinical nephrology (Clin Nephrol) Vol. 87 (2017) Issue 5 Pg. 261-266 (May 2017) ISSN: 0301-0430 [Print] Germany
• PMID: 28332476 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiviral Agents

Topics

• Adult
• Aged, 80 and over
• Antiviral Agents (therapeutic use)
• Female
• Glomerulonephritis (drug therapy)
• Hepatitis C (complications, drug therapy, virology)
• Humans
• Sustained Virologic Response