Sleep Duration and Cardiometabolic Risk Among Chinese School-aged Children: Do Adipokines Play a Mediating Role?
Abstract | Study Objectives: To assess the associations between sleep duration and cardiometabolic risk factors in Chinese school-aged children and to explore the possible mediating role of adipokines. Methods: Results: Among the 6- to 12-year-old children, after adjusting for covariates including puberty, short sleep duration was associated with increased body mass index (BMI), waist circumference, fasting glucose, insulin and homeostasis model assessment of insulin resistance (all p < .0001), higher triglyceride and lower high-density lipoprotein cholesterol (p < .05), along with increased leptin (p < .0001), FGF21 (p < .05) and decreased HMW- adiponectin (p ≤ .01); the association with leptin remained significant after further adjustment for BMI. However, these associations, except for glucose (p < .0001), disappeared after further adjusted for leptin. For the 13-18 years old group, short sleep duration was associated with higher BMI, waist circumference, and RBP4 (all p < .05), but the association with RBP4 was attenuated after adjusting for BMI (p = .067). Conclusions: Short sleep duration is strongly associated with obesity and hyperglycemia (in 6-12 years old), along with adverse adipokine secretion patterns among Chinese children. The associations with cardiometabolic risk factors appear to be more pronounced in younger children, and could be explained, at least partially, by leptin levels.
|
Authors | Lujiao Li, Junling Fu, Xin Ting Yu, Ge Li, Lu Xu, Jinghua Yin, Hong Cheng, Dongqing Hou, Xiaoyuan Zhao, Shan Gao, Wenhui Li, Changhong Li, Struan F A Grant, Mingyao Li, Yi Xiao, Jie Mi, Ming Li |
Journal | Sleep
(Sleep)
Vol. 40
Issue 5
(05 01 2017)
ISSN: 1550-9109 [Electronic] United States |
PMID | 28329079
(Publication Type: Journal Article)
|
Copyright | © Sleep Research Society 2017. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail [email protected]. |
Chemical References |
- Adipokines
- Adiponectin
- Blood Glucose
- Cholesterol, HDL
- Insulin
- Leptin
- RBP4 protein, human
- RETN protein, human
- Resistin
- Retinol-Binding Proteins, Plasma
- Triglycerides
- fibroblast growth factor 21
- Fibroblast Growth Factors
|
Topics |
- Adipokines
(blood, metabolism)
- Adiponectin
(blood)
- Adolescent
- Asian People
- Blood Glucose
(analysis)
- Body Mass Index
- Cardiovascular Diseases
(blood, metabolism)
- Child
- China
(ethnology)
- Cholesterol, HDL
(blood)
- Female
- Fibroblast Growth Factors
(blood)
- Humans
- Hyperglycemia
(blood, metabolism)
- Insulin
(blood)
- Insulin Resistance
- Leptin
(blood)
- Male
- Metabolic Syndrome
(blood, metabolism)
- Obesity
(blood, metabolism)
- Resistin
(blood)
- Retinol-Binding Proteins, Plasma
(analysis, metabolism)
- Risk Factors
- Sleep
(physiology)
- Time Factors
- Triglycerides
(blood)
- Waist Circumference
|
|
Join CureHunter, for free Research Interface BASIC access!
Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease.
Find out why thousands of doctors, pharma researchers and patient activists
around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!
|