[11C]5-hydroxy-tryptophan PET for Assessment of Islet Mass During Progression of Type 2 Diabetes.

Abstract

[11C]5-hydroxy-tryptophan ([11C]5-HTP) positron emission tomography of the pancreas has been shown to be a surrogate imaging biomarker of pancreatic islet mass. The change in islet mass in different stages of type 2 diabetes (T2D) as measured by noninvasive imaging is currently unknown. Here, we describe a cross-sectional study where subjects at different stages of T2D development with expected stratification of pancreatic islet mass were examined in relation to individuals without diabetes. The primary outcome was the [11C]5-HTP uptake and retention in pancreas, as a surrogate marker for the endogenous islet mass. We found that metabolic testing indicated a progressive loss of β-cell function, but this was not mirrored by a decrease in [11C]5-HTP tracer accumulation in the pancreas. This provides evidence of retained islet mass despite decreased β-cell function. The results herein indicate that β-cell dedifferentiation, and not necessarily endocrine cell loss, constitutes a major cause of β-cell failure in T2D.

• Authors: Lina Carlbom, Daniel Espes, Mark Lubberink, Mats Martinell, Lars Johansson, Håkan Ahlström, Per-Ola Carlsson, Olle Korsgren, Olof Eriksson
• Journal: Diabetes (Diabetes) Vol. 66 Issue 5 Pg. 1286-1292 (05 2017) ISSN: 1939-327X [Electronic] United States
• PMID: 28246291 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2017 by the American Diabetes Association.

Chemical References

• Blood Glucose
• C-Peptide
• Carbon Radioisotopes
• Hypoglycemic Agents
• Insulin
• Arginine
• 5-Hydroxytryptophan
• Glucose

Topics

• 5-Hydroxytryptophan
• Aged
• Arginine
• Blood Glucose (metabolism)
• C-Peptide (blood)
• Carbon Radioisotopes
• Case-Control Studies
• Cell Differentiation
• Cross-Sectional Studies
• Diabetes Mellitus, Type 2 (diagnostic imaging, drug therapy, metabolism, pathology)
• Disease Progression
• Female
• Glucose
• Humans
• Hypoglycemic Agents (therapeutic use)
• Insulin (therapeutic use)
• Insulin-Secreting Cells (metabolism, pathology)
• Islets of Langerhans (diagnostic imaging, metabolism, pathology)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Organ Size
• Positron Emission Tomography Computed Tomography