Abstract | BACKGROUND: Musclin is a newly identified skeletal muscle-derived secretory factor, which has been recently characterized as a stimulator that induces insulin resistance in mice. However, the pathophysiological role of musclin in humans remains poorly understood. The aim of this study was to explore the potential correlations between musclin plasma levels and various metabolic parameters in patients with type 2 diabetes mellitus. MATERIALS AND METHODS: In this hospital-based study, plasma samples were collected from the enrolled individuals, including 38 newly diagnosed, treatment-naive type 2 diabetes mellitus patients and 41 age- and gender-matched control subjects. Plasma musclin levels were examined by radioimmunoassay. RESULTS: CONCLUSION:
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Authors | Wen-Jia Chen, Yue Liu, Yu-Bin Sui, Bo Zhang, Xiao-Hui Zhang, Xin-Hua Yin |
Journal | Diabetes & vascular disease research
(Diab Vasc Dis Res)
Vol. 14
Issue 2
Pg. 116-121
(03 2017)
ISSN: 1752-8984 [Electronic] England |
PMID | 28185530
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Blood Glucose
- Glycated Hemoglobin A
- Insulin
- Muscle Proteins
- OSTN protein, human
- Transcription Factors
- Triglycerides
- hemoglobin A1c protein, human
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Topics |
- Adult
- Area Under Curve
- Biomarkers
(blood)
- Blood Glucose
(analysis)
- Case-Control Studies
- Diabetes Mellitus, Type 2
(blood, diagnosis)
- Female
- Glycated Hemoglobin
(analysis)
- Humans
- Insulin
(blood)
- Insulin Resistance
- Linear Models
- Logistic Models
- Male
- Middle Aged
- Multivariate Analysis
- Muscle Proteins
(blood)
- Odds Ratio
- Predictive Value of Tests
- ROC Curve
- Radioimmunoassay
- Transcription Factors
(blood)
- Triglycerides
(blood)
- Up-Regulation
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