Erythroid Differentiation Regulator 1 as a Novel Biomarker for Hair Loss Disorders.

Abstract

Erythroid differentiation regulator 1 (Erdr1) is known to be involved in the inflammatory process via regulating the immune system in many cutaneous disorders, such as psoriasis and rosacea. However, the role of Erdr1 in various hair loss disorders remains unclear. The aim of this study was to investigate the putative role of Erdr1 in alopecias. Skin samples from 21 patients with hair loss disorders and five control subjects were retrieved, in order to assess their expression levels of Erdr1. Results revealed that expression of Erdr1 was significantly downregulated in the epidermis and hair follicles of patients with hair loss disorders, when compared to that in the control group. In particular, the expression of Erdr1 was significantly decreased in patients with alopecia areata. We propose that Erdr1 downregulation might be involved in the pathogenesis of hair loss, and could be considered as a novel biomarker for hair loss disorders.

• Authors: Yu Ri Woo, Sewon Hwang, Seo Won Jeong, Dae Ho Cho, Hyun Jeong Park
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 18 Issue 2 (Feb 03 2017) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 28165377 (Publication Type: Journal Article)

Chemical References

• Biomarkers
• Membrane Proteins
• Tumor Suppressor Proteins
• erythroid differentiation regulator 1, human

Topics

• Alopecia (diagnosis, genetics, metabolism)
• Biomarkers
• Case-Control Studies
• Down-Regulation
• Epidermis (metabolism, pathology)
• Epithelium (metabolism, pathology)
• Gene Expression
• Hair Follicle (metabolism)
• Humans
• Immunohistochemistry
• Membrane Proteins (genetics, metabolism)
• Tumor Suppressor Proteins (genetics, metabolism)