Abstract | INTRODUCTION: METHODS: A total of 238 MDD patients treated for an acute episode of depression, 132 BD patients in treatment with mood stabilizers for a manic or mixed episode, and 324 controls were genotyped for rs1800866. At discharge, response to treatments was evaluated in MDD and BD patients by the Hamilton Rating Scale for Depression (HRSD) and the Young Mania Rating Score (YMRS), respectively. RESULTS: In our Korean sample, allele frequencies were different from those reported in other Asian and non-Asian populations. The CC genotype was associated with BD and, as a trend, with MDD. No significant effect was observed on response to antidepressants in MDD or mood stabilizers in BD, although the CC genotype was more frequent among BD patients experiencing a mixed episode. CONCLUSION:
|
Authors | Laura Mandelli, Sheng-Min Wang, Changsu Han, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae, Alessandro Serretti |
Journal | Advances in therapy
(Adv Ther)
Vol. 34
Issue 3
Pg. 713-724
(03 2017)
ISSN: 1865-8652 [Electronic] United States |
PMID | 28144920
(Publication Type: Journal Article)
|
Chemical References |
- Antidepressive Agents
- Receptors, sigma
|
Topics |
- Adult
- Antidepressive Agents
(therapeutic use)
- Bipolar Disorder
(diagnosis, drug therapy, genetics)
- Depressive Disorder, Major
(diagnosis, drug therapy, genetics)
- Female
- Humans
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- Psychiatric Status Rating Scales
- Receptors, sigma
(genetics)
- Republic of Korea
- Synaptic Transmission
(genetics)
- Sigma-1 Receptor
|