Differences in inflammatory marker patterns for adult community-acquired pneumonia patients induced by different pathogens.

Abstract

INTRODUCTION:

The inflammatory marker patterns of community-acquired Pneumonia (CAP) induced by different microorganisms in adult patients remained unclear.

OBJECTIVES:

We aim to explore the inflammatory marker patterns of adult CAP patients induced by different pathogens.

METHODS:

Adult CAP patients with definite etiologies were enrolled from September 2010 to June 2012. They were divided into three groups according to the causative pathogens: typical bacteria, Mycoplasma pneumoniae (MP), and viruses. Twenty-seven cytokines and bactericidal/permeability-increasing protein (BPI) levels of serum collected within 7 days onset in these groups were compared.

RESULTS:

One hundred twenty-four cases were enrolled for serum detection and analysis, including 10 typical bacterial pneumonia patients, 56 cases with MP pneumonia and 58 with viral pneumonia. Three kinds (PDGF-BB, IP-10, RANTES) of 27 cytokines and BPI levels were significantly elevated in patients with acute pneumonia than healthy controls. Distinct inflammatory marker patterns were released by different pathogens: typical bacterial pneumonia patients had highest levels of BPI, IL-6, IL-8, IL-1rα; while patients caused by MP presented higher levels of PDGF-BB, IL-17A, G-CSF than those caused by viruses. Rhinovirus owned a higher inflammatory response level than the other viruses. The area under the curve (AUC) of PDGF-BB to differentiate MP and virus infection was biggest, which was 0.708.

CONCLUSION:

Distinct inflammatory marker patterns were released by different pathogens during acute pneumonia. Significantly increased level of PDGF-BB was observed in acute pneumonia for the first time. It showed a better ability to differentiate MP and virus infection.

• Authors: Meng Liu, Hui Li, Chun Xue Xue, Li Gu, Jiu Xin Qu, Xiao Min Yu, Yi Min Wang, Ying Mei Liu, Bin Cao
• Journal: The clinical respiratory journal (Clin Respir J) Vol. 12 Issue 3 Pg. 974-985 (Mar 2018) ISSN: 1752-699X [Electronic] England
• PMID: 28139879 (Publication Type: Comparative Study, Journal Article)
• Copyright: © 2017 John Wiley & Sons Ltd.

Chemical References

• BPIFB2 protein, human
• Biomarkers
• Carrier Proteins
• Cytokines
• Proto-Oncogene Proteins c-sis
• Becaplermin

Topics

• Adult
• Aged
• Becaplermin
• Biomarkers (blood)
• Carrier Proteins (blood)
• Community-Acquired Infections (blood, epidemiology, microbiology, virology)
• Cytokines (blood)
• Female
• Humans
• Male
• Middle Aged
• Mycoplasma pneumoniae (isolation & purification)
• Pneumonia (blood, diagnosis, microbiology, virology)
• Pneumonia, Bacterial (blood, diagnosis, microbiology)
• Pneumonia, Mycoplasma (blood, diagnosis, microbiology)
• Pneumonia, Viral (blood, diagnosis, virology)
• Prospective Studies
• Proto-Oncogene Proteins c-sis (blood)
• Rhinovirus (isolation & purification)