Limited cutaneous systemic sclerosis arising in a patient with Graves' disease.

Abstract

Although Graves' disease and systemic sclerosis are both autoimmune disorders, their relationship is rarely reported. We present the case of a Filipino woman with goitre and thyrotoxic signs and symptoms. Diagnosed with Graves' disease at the outpatient clinic, she took antithyroid medications and underwent radioactive iodine ablation with resultant hypothyroidism after 6 months, during which she began to experience skin tightness over the face, neck and fingers. Workup revealed limited cutaneous systemic sclerosis, and the patient improved with methotrexate. This case highlights the increased prevalence of coincident autoimmune disorders in Graves' disease.

• Authors: Marc Gregory Yu, John Paul Montinola Quisumbing
• Journal: BMJ case reports (BMJ Case Rep) Vol. 2017 (Jan 27 2017) ISSN: 1757-790X [Electronic] England
• PMID: 28130289 (Publication Type: Case Reports, Journal Article)
• Copyright: 2017 BMJ Publishing Group Ltd.

Chemical References

• Antithyroid Agents
• Immunosuppressive Agents
• Iodine Radioisotopes
• Methimazole
• Thyroxine
• Methotrexate

Topics

• Adult
• Antithyroid Agents (therapeutic use)
• Facial Dermatoses (complications, drug therapy)
• Female
• Graves Disease (complications, drug therapy)
• Hormone Replacement Therapy
• Humans
• Hypothyroidism (chemically induced, drug therapy)
• Immunosuppressive Agents (therapeutic use)
• Iodine Radioisotopes (therapeutic use)
• Methimazole (therapeutic use)
• Methotrexate (therapeutic use)
• Neck
• Scleroderma, Limited (complications, drug therapy)
• Thyroxine (therapeutic use)