Abstract | BACKGROUND: MATERIAL AND METHODS: Patients with MPM of clinical stage I-III, which were macroscopic completely resected with EPP were eligible for this prospective study. The ipsilateral hemithorax was irradiated with a prescribed dose of 50.4 Gy. When the high-risk surgical margins or FDG-avid regions were identified, simultaneous integrated boost (SIB) with 56.0 Gy or 61.6 Gy was applied. RESULTS: Twenty-one patients were enrolled. SIB was applied to five patients. The planned IMRT fractions were completed in all, but four patients who suffered from severe fatigue or radiation pneumonitis. With a potential median follow-up of 6.3 years, overall survival was 37.5% at 3 years since the IMRT. The median survival time was 17.5 and 27.0 months since the IMRT and the initial treatment, respectively. Three patients have survived for more than 5 years. Distant metastasis was observed in 15 patients. Local recurrence was also observed in 2 of the 15 patients. Acute toxicities of Grade 3 or worse were observed in 15 patients, including 9 with hematological, 3 with pneumonitis and 6 with fatigue, nausea or vomiting. Five patients developed Grade 3 or worse late toxicities associated with IMRT, consisting of one with persistent Grade 4 thrombocytopenia, one with brain infarction and congestive liver dysfunction, and three with elevation of serum transaminase or biliary enzyme. No Grade 5 toxicity was observed. Patients with N2 showed significantly worse survival than those with N0-1 (18.2% vs. 60.0% at 3 years, p = .014). CONCLUSION: IMRT following EPP achieved excellent local control for MPM, that might lead to the long-term survival in selected patients. However, treatment burden including acute and late toxicities should be considered in this treatment approach.
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Authors | Yukinori Matsuo, Keiko Shibuya, Kenichi Okubo, Nami Ueki, Akihiro Aoyama, Makoto Sonobe, Mitsuhiro Nakamura, Takashi Mizowaki, Hiroshi Date, Masahiro Hiraoka |
Journal | Acta oncologica (Stockholm, Sweden)
(Acta Oncol)
Vol. 56
Issue 7
Pg. 957-962
(Jul 2017)
ISSN: 1651-226X [Electronic] England |
PMID | 28117611
(Publication Type: Journal Article)
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Topics |
- Aged
- Female
- Follow-Up Studies
- Humans
- Lung Neoplasms
(pathology, radiotherapy, surgery)
- Male
- Mesothelioma
(pathology, radiotherapy, surgery)
- Mesothelioma, Malignant
- Middle Aged
- Neoplasm Recurrence, Local
(pathology, radiotherapy, surgery)
- Pleural Neoplasms
(pathology, radiotherapy, surgery)
- Pneumonectomy
(mortality)
- Prevalence
- Prognosis
- Prospective Studies
- Radiation Pneumonitis
(epidemiology)
- Radiotherapy, Intensity-Modulated
(mortality)
- Survival Rate
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