Topical 0.1% Bromfenac Sodium for Intraoperative Miosis Prevention and Prostaglandin E2 Inhibition in Femtosecond Laser-Assisted Cataract Surgery.

Abstract

PURPOSE:

The purpose of this study was to evaluate the effect of topical 0.1% bromfenac sodium, a nonsteroidal anti-inflammatory drug (NSAID), on intraoperative pupil dilation maintenance and prostaglandin E2 (PGE2) inhibition during femtosecond laser-assisted cataract surgery.

METHODS:

Sixty patients (30 each in study and control groups) were included in this study. The patients received 0.1% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil size was measured at the initiation of femtosecond laser pretreatment and phacoemulsification. Aqueous humor was collected at the beginning of routine cataract surgery. PGE2 levels were measured with an enzyme-linked immunoassay. Laser flare photometry was measured preoperatively and at 1 day postoperatively.

RESULTS:

Compared with untreated patients, the change in pupil size and postoperative day 1 aqueous flare were significantly reduced throughout the operation in the patients treated with 0.1% bromfenac (P < 0.001). Mean PGE2 concentrations were also significantly decreased by treatment with 0.1% bromfenac (P < 0.001). The reduction of the pupil area and postoperative day 1 aqueous flare were significantly correlated with PGE2 levels (P < 0.001).

CONCLUSION:

NSAID treatment, when administered before femtosecond laser-assisted cataract surgery, was effective in maintaining intraoperative pupil dilation, preventing miosis, and reducing PGE2 levels.

• Authors: Hui Chen, Haotian Lin, Wan Chen, Bo Zhang, Wu Xiang, Jing Li, Weirong Chen
• Journal: Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) Vol. 33 Issue 3 Pg. 193-201 (04 2017) ISSN: 1557-7732 [Electronic] United States
• PMID: 28106471 (Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Benzophenones
• Bromobenzenes
• Receptors, Prostaglandin E, EP2 Subtype
• bromfenac

Topics

• Administration, Topical
• Aged
• Benzophenones (administration & dosage, pharmacology)
• Bromobenzenes (administration & dosage, pharmacology)
• Cataract (complications, metabolism)
• Cataract Extraction
• Double-Blind Method
• Female
• Humans
• Intraoperative Complications (prevention & control)
• Lasers
• Male
• Middle Aged
• Miosis (prevention & control)
• Prospective Studies
• Receptors, Prostaglandin E, EP2 Subtype (antagonists & inhibitors)
• Time Factors