Chronic Pruritus in an 18-Month-Old Male Infant Due to Anicteric Cholestasis.

Abstract

An 18-month-old male infant was referred to us with pruritus from 6 months of age. He was being managed as atopic eczema with emollients and antihistamines without any response to treatment. On examination, he was found to have extensive scratch marks, mild hepatomegaly and no icterus. Blood investigations were suggestive of anicteric cholestatic liver disease. Liver biopsy was suggestive of progressive familial intrahepatic cholestasis type 3. He showed symptomatic improvement after starting ursodeoxycholic acid and fat-soluble vitamins and is under follow up.

• Authors: Vishnu S Nair, Venkatesh Chandrasekaran, Barath Jagadisan, Niranjan Biswal
• Journal: Journal of tropical pediatrics (J Trop Pediatr) Vol. 63 Issue 4 Pg. 321-323 (08 01 2017) ISSN: 1465-3664 [Electronic] England
• PMID: 28082665 (Publication Type: Case Reports, Journal Article)
• Copyright: © The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].

Chemical References

• ATP Binding Cassette Transporter, Subfamily B
• Ursodeoxycholic Acid

Topics

• ATP Binding Cassette Transporter, Subfamily B (deficiency, genetics)
• Biopsy
• Cholestasis (complications, diagnosis, genetics)
• Cholestasis, Intrahepatic (drug therapy, genetics, pathology)
• Chronic Disease
• Humans
• Infant
• Liver (pathology)
• Male
• Pruritus (etiology)
• Treatment Outcome
• Ursodeoxycholic Acid (therapeutic use)