Different clinical significance of FGFR1-4 expression between diffuse-type and intestinal-type gastric cancer.

Abstract

BACKGROUND:

Receptor tyrosine kinases promote tumor progression in many cancers, although oncologic activation differs between diffuse-type gastric cancer (DGC) and intestinal-type gastric cancer (IGC). Fibroblast growth factor receptor (FGFR) is one RTK, and we previously reported the clinical significance of FGFR1, 2, 3, and 4 in gastric cancer. The aim of the present study was to reevaluate the clinical significance of FGFR1-4 expression separately in DGC and IGC.

METHODS:

Tumor samples, including 109 DGCs and 100 IGCs, were obtained from patients who underwent gastrectomy between 2003 and 2007 in our institution. The expression levels of FGFR1, 2, 3, and 4 were measured in the tumors by immunohistochemical analysis.

RESULTS:

In DGC, high expression of FGFR1, FGFR2, or FGFR4 was significantly associated with the depth of invasion, lymph-node metastasis, pathological stage, and distant metastasis or recurrent disease. Patients with high expression of FGFR1, FGFR2, or FGFR4 had significantly poorer disease-specific survival (DSS) (p = 0.009, p = 0.001, and p = 0.023, respectively). In IGC, only FGFR4 expression was significantly associated with factors relative to tumor progression and with shorter DSS (p = 0.012).

CONCLUSION:

In conclusion, high FGFR4 expression correlated with tumor progression and survival in both DGC and IGC, whereas high expression of FGFR1 and 2 correlated with tumor progression and survival in only DGC.

• Authors: Mikito Inokuchi, Hideaki Murase, Sho Otsuki, Tatsuyuki Kawano, Kazuyuki Kojima
• Journal: World journal of surgical oncology (World J Surg Oncol) Vol. 15 Issue 1 Pg. 2 (Jan 05 2017) ISSN: 1477-7819 [Electronic] England
• PMID: 28056982 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• FGFR1 protein, human
• FGFR2 protein, human
• FGFR3 protein, human
• FGFR4 protein, human
• Receptor, Fibroblast Growth Factor, Type 1
• Receptor, Fibroblast Growth Factor, Type 2
• Receptor, Fibroblast Growth Factor, Type 3
• Receptor, Fibroblast Growth Factor, Type 4

Topics

• Aged
• Biomarkers, Tumor (metabolism)
• Female
• Follow-Up Studies
• Gastrectomy
• Humans
• Immunoenzyme Techniques
• Intestinal Neoplasms (metabolism, secondary, surgery)
• Lymphatic Metastasis
• Male
• Neoplasm Invasiveness
• Neoplasm Recurrence, Local (metabolism, pathology, surgery)
• Neoplasm Staging
• Prognosis
• Receptor, Fibroblast Growth Factor, Type 1 (metabolism)
• Receptor, Fibroblast Growth Factor, Type 2 (metabolism)
• Receptor, Fibroblast Growth Factor, Type 3 (metabolism)
• Receptor, Fibroblast Growth Factor, Type 4 (metabolism)
• Stomach Neoplasms (metabolism, pathology, surgery)
• Survival Rate