Biological characteristics of CCN proteins in tumor development.

Abstract

The extracellular membrane (ECM) is no longer regarded as inert, rather it has multiple versatile physiologic functions. Its diverse composition is implicated in each step of cancer progression including inflammation, angiogenesis, tumor invasion and metastasis. In addition to structural proteins, the ECM also contains a family of non-structural proteins called matricellular proteins. The six secreted CCN proteins, which belong to the matricellular protein family, include the following: Cyr61 (CCN1), CTGF (CCN2), Nov (CCN3), WISP- 1 (CCN4), WISP-2 (CCN5) and WISP-3(CCN6). These proteins are capable of modulating a variety of biological processes in health as well as in disease conditions. In tumor development and in tumor microenvironment, CCN proteins can influence multiple facets of pathophysiological processes including cellular proliferation, invasion and metastasis. This review has attempted a cohesive look at the CCN family protein functions in a tumor-specific manner.

• Authors: Stephany C Barreto, Amitabha Ray, Page Ag Edgar
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2016 Nov-Dec Vol. 21 Issue 6 Pg. 1359-1367 ISSN: 1107-0625 [Print] Cyprus
• PMID: 28039692 (Publication Type: Journal Article, Review)

Chemical References

• CCN Intercellular Signaling Proteins

Topics

• Animals
• CCN Intercellular Signaling Proteins (metabolism)
• Cell Movement
• Cell Proliferation
• Extracellular Matrix (metabolism, pathology)
• Humans
• Neoplasm Invasiveness
• Neoplasms (metabolism, pathology)
• Signal Transduction
• Tumor Microenvironment