Abstract | PURPOSE: METHODS: FBF (Doppler ultrasound) was assessed at rest and during 5 min of dynamic forearm handgrip exercise at 15% of maximal voluntary contraction under control (saline) conditions and during 3 experimental protocols: (1) oral SDF (n = 10), (2) intra-arterial L-NMMA (n = 20), (3) SDF and L-NMMA (n = 10). FBF responses to intra-arterial sodium nitroprusside (NTP, NO donor) were also assessed. RESULTS: FBF increased with exercise (p < 0.01). Intra-arterial infusion of L-NMMA resulted in a reduction in exercise hyperemia (17 ± 1 to 15 ± 1 mL/dL/min, p < 0.01). Although the hyperemic response to NTP was augmented by SDF (area under the curve: 41 ± 7 vs 61 ± 11 AU, p < 0.01), there was no effect of SDF on exercise hyperemia (p = 0.33). CONCLUSIONS: Despite improving NTP-mediated vasodilation, oral SDF failed to augment exercise hyperemia in young, healthy adults. These observations reflect a minor contribution of NO and the cGMP pathway during exercise hyperemia in healthy young humans.
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Authors | Jacqueline K Limberg, Katherine R Malterer, J Mikhail Kellawan, William G Schrage, Brad W Wilkins, Wayne T Nicholson, John H Eisenach, Michael J Joyner, Timothy B Curry |
Journal | European journal of applied physiology
(Eur J Appl Physiol)
Vol. 117
Issue 2
Pg. 237-246
(Feb 2017)
ISSN: 1439-6327 [Electronic] Germany |
PMID | 28013386
(Publication Type: Journal Article)
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Chemical References |
- Enzyme Inhibitors
- Nucleotides, Cyclic
- Phosphodiesterase 5 Inhibitors
- cyclic guanosine monophosphate-adenosine monophosphate
- Nitroprusside
- Nitric Oxide
- Sildenafil Citrate
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Topics |
- Adult
- Blood Pressure
(drug effects, physiology)
- Enzyme Inhibitors
(pharmacology)
- Exercise
(physiology)
- Female
- Hand Strength
(physiology)
- Hemodynamics
(drug effects, physiology)
- Humans
- Hyperemia
(physiopathology)
- Male
- Nitric Oxide
(metabolism)
- Nitroprusside
(pharmacology)
- Nucleotides, Cyclic
(metabolism)
- Phosphodiesterase 5 Inhibitors
(pharmacology)
- Sildenafil Citrate
(administration & dosage, pharmacology)
- Vasodilation
(drug effects, physiology)
- Young Adult
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