Prevention of hypertension-induced vascular dementia by Lactobacillus paracasei subsp. paracasei NTU 101-fermented products.

Abstract

CONTEXT:

Numerous etiological studies have established positive clinical association between hypertension and vascular dementia (VaD). Lactobacillus paracasei subsp. paracasei NTU 101-fermented products have been shown to decrease vascular risk factors such as hypertension, atherosclerosis, hyperlipidemia and obesity.

OBJECTIVE:

This study investigated the effect of ethanol extract of Lactobacillus paracasei subsp. paracasei NTU 101-fermented products (NTU101F) in hypertension-induced VaD in rats.

MATERIALS AND METHODS:

Hypertension was promoted by subcutaneous injection of deoxycorticosterone acetate (DOCA, 25 mg/kg body weight/day, twice a week) and substitution of drinking water with 1.0% NaCl and 0.2% KCl. The NTU101F groups (0.5, 1.0, and 5.0) administered NTU101F at the concentrations 11, 22, and 110 mg/kg body weight/day, respectively, starting from day 51 day of DOCA-salt treatment. Morris water maze (MWM) was used for testing learning and memory. Different biochemical estimations were used to assess oxidative stress and inflammatory response in hippocampus.

RESULTS:

Oral administration of NTU101F in DOCA-salt hypertension-induced VaD rats resulted in a significant decrease in blood pressure by 18.3-23.2% (p < 0.001), which was regulated by increasing eNOS density (about 3-fold) in the aorta, promoting NO production, and decreasing of matrix metallopeptidase 9 activity (about 2-fold) in the hippocampus, in addition to improve the kidney function and structure, decrease escape latency and increase the times spent in the target quadrant by 23.5-27.8% (p < 0.05).

CONCLUSION:

Overall, our findings suggest that NTU101F could exert neuroprotection in the brain and attenuate hypertension-induced VaD.

• Authors: Meng-Chun Cheng, Tzu-Ming Pan
• Journal: Pharmaceutical biology (Pharm Biol) Vol. 55 Issue 1 Pg. 487-496 (Dec 2017) ISSN: 1744-5116 [Electronic] England
• PMID: 27937042 (Publication Type: Journal Article)

Chemical References

• Cytokines
• Inflammation Mediators
• Nitric Oxide
• Desoxycorticosterone Acetate
• Elastin
• Nitric Oxide Synthase Type III
• Nos3 protein, rat
• Matrix Metalloproteinase 9
• Mmp9 protein, rat

Topics

• Animals
• Aorta (drug effects, metabolism, physiopathology)
• Behavior, Animal (drug effects)
• Blood Pressure (drug effects)
• Cultured Milk Products
• Cytokines (metabolism)
• Dementia (etiology, physiopathology, prevention & control, psychology)
• Desoxycorticosterone Acetate
• Dietary Supplements
• Disease Models, Animal
• Elastin (metabolism)
• Escape Reaction (drug effects)
• Hippocampus (drug effects, metabolism, physiopathology)
• Hypertension (chemically induced, metabolism, physiopathology, therapy)
• Inflammation Mediators (metabolism)
• Kidney (drug effects, pathology, physiopathology)
• Lipid Peroxidation (drug effects)
• Male
• Matrix Metalloproteinase 9 (metabolism)
• Maze Learning (drug effects)
• Memory (drug effects)
• Nitric Oxide (metabolism)
• Nitric Oxide Synthase Type III (metabolism)
• Oxidative Stress (drug effects)
• Rats, Wistar
• Time Factors