Undervaccination with diphtheria, tetanus, and pertussis vaccine: National trends and association with pertussis risk in young children.

Abstract

BACKGROUND:

The high coverage for ≥3 pertussis vaccine doses among Taiwanese children might not imply timely vaccination. Recently, resurgence of pertussis and challenges with availability of DTaP-IPV-Hib prompted this study.

METHODS:

In the 1996-2012 national birth cohort, we calculated the prevalence and days of undervaccination against pertussis by age 36 months. We also compared the odds of undervaccination in each laboratory-confirmed pertussis patient at ages 3-35 months with sex-, residence-, and age-matched controls from the general population, using conditional logistic regression.

RESULTS:

The prevalence of undervaccination was 60.6% (median 16 days) and decreasing (p < 0.0001). Among 145 cases and 2,900 controls, 58 (40.0%) and 721 (24.9%) were undervaccinated (OR 2.28, 95% CI 1.57-3.31). The attributable risk percent was 22.5% (95% CI 14.5-27.9).

CONCLUSIONS:

Undervaccination was decreasing. Approximately up to one-fifth pertussis cases in children aged 3-35 months could have been prevented with on-time vaccination.

• Authors: Wan-Ting Huang, Hui-Chen Lin, Chin-Hui Yang
• Journal: Human vaccines & immunotherapeutics (Hum Vaccin Immunother) Vol. 13 Issue 4 Pg. 757-761 (04 03 2017) ISSN: 2164-554X [Electronic] United States
• PMID: 27858500 (Publication Type: Journal Article)

Chemical References

• Diphtheria-Tetanus-acellular Pertussis Vaccines

Topics

• Child, Preschool
• Diphtheria-Tetanus-acellular Pertussis Vaccines (administration & dosage, immunology)
• Female
• Humans
• Immunization (statistics & numerical data)
• Infant
• Infant, Newborn
• Male
• Retrospective Studies
• Risk Factors
• Taiwan (epidemiology)
• Whooping Cough (epidemiology, prevention & control)