Abstract | BACKGROUND: METHODS: Retrospective, controlled observational case study of 30 eyes with macular edema secondary to central retinal vein occlusion, which were treated with a dexamethasone implantation. Visual acuity, central retinal thickness and intraocular pressure were measured monthly. Analyses were performed separately for eyes with visual acuity <0.1 and ≥0.1. RESULTS: Two months post intervention, visual acuity improved only marginally from 0.05 to 0.07 (1 month; p = 0,065) and to 0.08 (2 months; p = 0,2) in patients with low visual acuity as compared to patients with visual acuity ≥0.1 with an improvement from 0.33 to 0.47 (1 month; p = 0,005) and to 0.49 (2 months; p = 0,003). The central retinal thickness, however, was reduced in both groups, falling from 694 to 344 μm (1 month; p = 0.003,) to 361 μm (2 months; p = 0,002) and to 415 μm (3 months; p = 0,004) in the low visual acuity group and from 634 to 315 μm (1 month; p < 0,001) and to 343 μm (2 months; p = 0,001) in the visual acuity group ≥0.1. Absence of visual acuity improvement was related to macular ischemia. CONCLUSIONS:
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Authors | Sibylle Winterhalter, Gerrit Alexander Vom Brocke, Daniel Pilger, Annabelle Eckert, Juliane Schlomberg, Anne Rübsam, Matthias Karl Klamann, Enken Gundlach, Tina Dietrich-Ntoukas, Antonia Maria Joussen |
Journal | BMC ophthalmology
(BMC Ophthalmol)
Vol. 16
Issue 1
Pg. 187
(Oct 27 2016)
ISSN: 1471-2415 [Electronic] England |
PMID | 27784291
(Publication Type: Journal Article, Observational Study)
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Chemical References |
- Drug Implants
- Glucocorticoids
- Dexamethasone
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Topics |
- Aged
- Aged, 80 and over
- Case-Control Studies
- Dexamethasone
(administration & dosage)
- Drug Implants
- Female
- Glucocorticoids
(administration & dosage)
- Humans
- Intravitreal Injections
- Male
- Middle Aged
- Retina
(pathology)
- Retinal Vein Occlusion
(complications, drug therapy, physiopathology)
- Retrospective Studies
- Vision, Low
(drug therapy, etiology)
- Visual Acuity
(physiology)
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