Abstract | BACKGROUND: METHODS: All patients with pulmonary hypertension undergoing pump implantation for the continuous application of intravenous treprostinil were included from two German centers. Surgery was performed under local or general anesthesia according to the protocol of the recruiting center. Intra-operative safety and in-hospital complications were analyzed for the two different implantation regimens. RESULTS: In total, 51 patients were included. No major intra-operative complications were recorded. During the observation period, two patients died of progressive right heart failure, and two patients required treatment in the intensive care unit for acute right heart decompensation and respiratory failure. In total, major complications occurred in 8 out of 51 patients. CONCLUSIONS: Our observational study provides preliminary evidence supporting the procedural safety of a fully implantable pump inserted under local or general anesthesia for patients with severe pulmonary hypertension. The observation of major complications in a subset of patients requires extensive pre- and post-operative assessments. Future trials are required to provide further evidence for the long-term safety and efficacy of the pump using this approach.
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Authors | Manuel J Richter, Ralf Ewert, Christian Warnke, Henning Gall, Simon Classen, Friedrich Grimminger, Eckhard Mayer, Werner Seeger, Hossein-Ardeschir Ghofrani |
Journal | Clinical research in cardiology : official journal of the German Cardiac Society
(Clin Res Cardiol)
Vol. 106
Issue 3
Pg. 174-182
(Mar 2017)
ISSN: 1861-0692 [Electronic] Germany |
PMID | 27670656
(Publication Type: Journal Article, Multicenter Study, Observational Study)
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Chemical References |
- Antihypertensive Agents
- Prostaglandins
- Epoprostenol
- treprostinil
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Topics |
- Adult
- Antihypertensive Agents
(administration & dosage)
- Epoprostenol
(administration & dosage, analogs & derivatives)
- Female
- Follow-Up Studies
- Humans
- Hypertension, Pulmonary
(drug therapy, physiopathology)
- Infusion Pumps, Implantable
- Male
- Middle Aged
- Prospective Studies
- Prostaglandins
(administration & dosage)
- Pulmonary Wedge Pressure
(physiology)
- Retrospective Studies
- Treatment Outcome
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