Abstract | BACKGROUND: METHODS: We searched PubMed, EMBASE, and the Central Registry of Controlled Trials of the Cochrane Library up to August 2016. We also searched the Proceedings of the American Society of Clinical Oncology (1986 to August 2016). Abstracts were manually searched to identify relevant trials. A total of three randomized controlled trials with 682 patients met the inclusion criteria. RESULTS: Our results demonstrated that bevacizumab combined with erlotinib significantly improved overall survival (hazard ratio 0.78; 95 % confidence interval 0.66-0.93; p = 0.006) and progression-free survival (hazard ratio 0.79; 95 % confidence interval 0.68-0.92; p = 0.002). Significantly more grade 3 rash, diarrhea, infection total, and fatigue were observed in the bevacizumab combined with erlotinib arm, which were controllable and reversible. CONCLUSIONS: Based on current evidence, the addition of erlotinib to bevacizumab as maintenance therapy significantly increases overall survival and progression-free survival with an increased but manageable toxicity in patients with mCRC. It should be considered as a treatment option for these patients under the premise of a reasonable selection of the target population.
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Authors | Wei Xu, Yang Gong, Meng Kuang, Peng Wu, Chunxiang Cao, Jinfei Chen, Cuiju Tang |
Journal | Clinical drug investigation
(Clin Drug Investig)
Vol. 37
Issue 2
Pg. 155-165
(Feb 2017)
ISSN: 1179-1918 [Electronic] New Zealand |
PMID | 27665469
(Publication Type: Journal Article, Meta-Analysis, Review)
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Chemical References |
- Angiogenesis Inhibitors
- Antineoplastic Agents
- Bevacizumab
- Erlotinib Hydrochloride
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Topics |
- Angiogenesis Inhibitors
- Antineoplastic Agents
(administration & dosage)
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Bevacizumab
(administration & dosage)
- Colorectal Neoplasms
(drug therapy)
- Disease-Free Survival
- Erlotinib Hydrochloride
(administration & dosage)
- Humans
- Neoplasm Metastasis
- Survival Analysis
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