Abstract | BACKGROUND: METHODS: The study population comprises adults admitted to the University of Virginia Medical Center between January 1, 2002 and December 31, 2012 who suffered AKI during admission. Long-term outcomes, MACE and all-cause mortality, were compared between 2 groups; patients with preexisting diagnosis of major depression and those without. Risk adjusted multivariable Cox proportional hazards regression examined the association between major depression and these outcomes. RESULTS: Patients with AKI numbering 11,425 survived beyond 90 days and had data available. Of these patients, 2,519 (22%) were majorly affected by depression; more often, younger patients, females, African Americans, and those with more comorbid conditions, especially CHF, CVD, diabetes, peptic ulcer disease, chronic pulmonary disease and liver disease were found to be affected with depression. Crude hazard ratio for MACE was 1.245, 95% CI 1.150-1.348 and for all-cause mortality 1.186, 95% CI 1.091-1.290; p < 0.001, that is, the cohort with major depression had a long-term risk for MACE and all-cause mortality increased by 24 and 18%, respectively. CONCLUSION: Patients who develop AKI in hospital and have preexisting major depression are at greater long-term risk of MACE and all-cause mortality.
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Authors | Rasheed A Balogun, Bolanle A Omotoso, Wenjun Xin, Jennie Z Ma, Kenneth W Scully, Fatiu A Arogundade, Emaad M Abdel-Rahman |
Journal | Nephron
(Nephron)
Vol. 135
Issue 1
Pg. 23-30
( 2017)
ISSN: 2235-3186 [Electronic] Switzerland |
PMID | 27655253
(Publication Type: Journal Article)
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Copyright | © 2016 S. Karger AG, Basel. |
Chemical References |
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Topics |
- Acute Kidney Injury
(complications, mortality, physiopathology)
- Adult
- Aged
- Cardiovascular Diseases
(epidemiology, etiology, mortality)
- Cohort Studies
- Creatinine
(blood)
- Depressive Disorder, Major
(complications, mortality)
- Female
- Glomerular Filtration Rate
- Humans
- Kidney Function Tests
- Male
- Middle Aged
- Prognosis
- Risk Factors
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