Epidemiology and prognostic factors of inpatient mortality of Guillain-Barré syndrome: A nationwide population study over 14years in Asian country.

Abstract

OBJECTIVE:

The present study aimed to evaluate the characteristics of inpatient mortality from Guillain-Barré syndrome (GBS), which is a rare and potentially life-threatening polyradiculoneuropathy, in an Asian country, as there are few big-data studies regarding this topic.

METHODS:

We obtained data regarding patients with GBS from Taiwan's National Health Insurance Research Database admission records. We identified patients with a discharge diagnosis of GBS during 2000-2013 using the International Classification of Diseases, 9th Revision, Clinical Modification code (357.0), and evaluated their baseline characteristics, clinical complications, and risk factors.

RESULTS:

We identified 5469 patients with GBS, and the crude incidence of GBS was 1.71 per 100,000 person-years. The inpatient mortality rate was 1.61% (88/5469) and 55 deaths (62.5% of all deaths) occurred before day 19 of the hospitalization (mainly during the progressive phase). The predictors of inpatient mortality included older age, a greater comorbidity burden (especially catastrophic illness), endotracheal intubation, mechanical ventilation, cardiac complications, and systemic infection. In contrast, patients who were admitted to a medical center or Neurology Department exhibited a higher survival rate.

CONCLUSIONS:

This 14-year nationwide study included the largest analysis of Asian patients with GBS to date, and identified various prognostic factors that predicted inpatient mortality.

• Authors: Li-Syue Liou, Chi-Hsiang Chung, Yung-Tsan Wu, Chang-Huei Tsao, Yung-Fu Wu, Wu-Chien Chien, Chih-Ya Chang
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 369 Pg. 159-164 (Oct 15 2016) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 27653883 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Community Health Planning
• Female
• Guillain-Barre Syndrome (epidemiology, mortality)
• Humans
• Incidence
• International Classification of Diseases
• Longitudinal Studies
• Male
• Middle Aged
• National Health Programs (statistics & numerical data)
• Retrospective Studies
• Taiwan (epidemiology)
• Young Adult