Serum YKL-40, a prognostic marker in patients with large-artery atherosclerotic stroke.

Abstract

BACKGROUND AND PURPOSE:

Inflammation comprises important aspects of large-artery atherosclerosis (LAA) stroke pathophysiology. YKL-40 is a new and emerging biomarker that is associated with both acute and chronic inflammations. Elevated serum concentrations of YKL-40 have been reported in patients with atherosclerosis and other cardiovascular diseases. This study investigates whether serum YKL-40 concentrations on admission can predict 3-month clinical outcomes after LAA stroke.

METHODS:

We recruited control patients (n=85) and those with LAA stroke (n=141) according to the TOAST classification system. The modified Rankin scale at 3 months after stroke was used to evaluate the prognosis. The prognostic accuracy was assessed by the receiver operating characteristic curve.

RESULTS:

Serum YKL-40 level was significantly higher for LAA patients than for controls (P<.001). Patients with poor outcomes (n=36) had significantly increased serum YKL-40 concentrations on admission (P=.01). High YKL-40 levels predicted poor functional outcome (OR=6.47, P=.02). Moreover, the combination of YKL-40 level and the NIHSS score could improve the prognostic accuracy of the NIHSS in predicting functional outcome (combined areas under the curve, 0.87; 95% CI, 0.80-0.94; P<.001).

CONCLUSIONS:

The level of serum YKL-40 is a significant and independent biomarker to predict the clinical outcome of LAA stroke.

• Authors: X-L Chen, Q Li, W-S Huang, Y-S Lin, J Xue, B Wang, K-L Jin, B Shao
• Journal: Acta neurologica Scandinavica (Acta Neurol Scand) Vol. 136 Issue 2 Pg. 97-102 (Aug 2017) ISSN: 1600-0404 [Electronic] Denmark
• PMID: 27650381 (Publication Type: Journal Article)
• Copyright: © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Biomarkers
• CHI3L1 protein, human
• Chitinase-3-Like Protein 1

Topics

• Adult
• Aged
• Atherosclerosis (blood, diagnostic imaging, epidemiology)
• Biomarkers (blood)
• Cerebral Arteries (diagnostic imaging)
• China (epidemiology)
• Chitinase-3-Like Protein 1 (blood)
• Female
• Humans
• Male
• Middle Aged
• Prognosis
• Stroke (blood, diagnostic imaging, epidemiology)