Abstract |
We transplanted autologous adrenal medullary cells to the caudate nucleus in 3 patients with progressive supranuclear palsy, using the method Madrazo has employed for neural transplantation in Parkinson's disease. Major and minor complications occurred post-operatively from which the patients recovered. One patient had a marked improvement in his postural stability and a decreased incidence of falling. This change was evident at 1 month after surgery and has remained for the 6 months of follow-up. Postural reflexes were not altered in the other 2 patients. There was no change in extraocular movements, speech, or the rigid-bradykinetic features of parkinsonism in any patient. Adrenal medullary transplantation has only limited efficacy in progressive supranuclear palsy.
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Authors | W C Koller, R Morantz, B Vetere-Overfield, M Waxman |
Journal | Neurology
(Neurology)
Vol. 39
Issue 8
Pg. 1066-8
(Aug 1989)
ISSN: 0028-3878 [Print] United States |
PMID | 2761701
(Publication Type: Journal Article)
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Topics |
- Adrenal Medulla
(transplantation)
- Aged
- Evaluation Studies as Topic
- Follow-Up Studies
- Humans
- Male
- Middle Aged
- Postoperative Complications
- Posture
- Reflex
- Supranuclear Palsy, Progressive
(physiopathology, surgery)
- Time Factors
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