Usefulness of Serum B-Type Natriuretic Peptide Levels in Comatose Patients Resuscitated from Out-of-Hospital Cardiac Arrest to Predict Outcome.

Abstract

N-terminal pro-B-type natriuretic (NT-proBNP) is expressed in the heart and brain, and serum levels are elevated in acute heart and brain diseases. We aimed to assess the possible association between serum levels and neurological outcome and death in comatose patients resuscitated from out-of-hospital cardiac arrest (OHCA). Of the 939 comatose OHCA patients enrolled and randomized in the Targeted Temperature Management (TTM) trial to TTM at 33°C or 36°C for 24 hours, 700 were included in the biomarker substudy. Of these, 647 (92%) had serum levels of NT-proBNP measured 24, 48, and 72 hours after return of spontaneous circulation (ROSC). Neurological outcome was evaluated by the Cerebral Performance Category (CPC) score and modified Rankin Scale (mRS) at 6 months. Six hundred thirty-eight patients (99%) had serum NT-proBNP levels ≥125 pg/ml. Patients with TTM at 33°C had significantly lower NT-proBNP serum levels (median 1,472 pg/ml) than those in the 36°C group (1,914 pg/ml) at 24 hours after ROSC, p <0.01 but not at 48 and 72 hours. At 24 hours, an increase in NT-proBNP quartile was associated with death (Plogrank <0.0001). In addition, NT-proBNP serum levels > median were independently associated with poor neurological outcome (odds ratio, ORCPC 2.02, CI 1.34 to 3.05, p <0.001; ORmRS 2.28, CI 1.50 to 3.46, p <0.001) adjusted for potential confounders. The association was diminished at 48 and 72 hours after ROSC. In conclusion, NT-proBNP serum levels are increased in comatose OHCA patients. Furthermore, serum NT-proBNP levels are affected by level of TTM and are associated with death and poor neurological outcome.

• Authors: Martin Frydland, Jesper Kjaergaard, David Erlinge, Pascal Stammet, Niklas Nielsen, Michael Wanscher, Tommaso Pellis, Hans Friberg, Jan Hovdenes, Janneke Horn, Jørn Wetterslev, Jakob H Thomsen, John Bro-Jeppesen, Matilde Winther-Jensen, Matthew P Wise, Michael Kuiper, Tobias Cronberg, Yvan Gasche, Yvan Devaux, Anders Åneman, Christian Hassager
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 118 Issue 7 Pg. 998-1005 (10 01 2016) ISSN: 1879-1913 [Electronic] United States
• PMID: 27614855 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2016 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain

Topics

• Adult
• Aged
• Biomarkers (blood)
• Cardiopulmonary Resuscitation
• Coma (blood)
• Female
• Humans
• Male
• Middle Aged
• Natriuretic Peptide, Brain (blood)
• Nervous System Diseases (blood, etiology)
• Odds Ratio
• Out-of-Hospital Cardiac Arrest (blood, complications, mortality, therapy)
• Peptide Fragments (blood)
• Prognosis
• Randomized Controlled Trials as Topic