Depression-like behaviors and heme oxygenase-1 are regulated by Lycopene in lipopolysaccharide-induced neuroinflammation.

Abstract

Previous studies have demonstrated that lycopene possesses anti-inflammatory properties in the central nervous system. However, the potential role and the molecular mechanisms of lycopene in lipopolysaccharide (LPS)-challenge inflammation and depression-like behaviors has not been clearly investigated. The present study aimed to assess the effects and the potential mechanisms of lycopene on LPS-induced depression-like behaviors. Lycopene was orally administered (60mg/kg) every day for seven days followed by intraperitoneal LPS injection (1mg/kg). The Forced swim test and tail suspension test were used to detect changes in the depression-like behaviors. ELISA was used to measure the expression of interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) in the plasma. Immunoblotting was performed to measure the expression of interleukin-1β (IL-1β) and heme oxygenase-1 (HO-1) in the hippocampus. The results showed that pretreatment with lycopene could ameliorate depression-like behaviors. Moreover, lycopene relieved neuronal cell injury in hippocampal CA1 regions. Furthermore, lycopene decreased LPS-induced expression of IL-1β and HO-1 in the hippocampus together with decreasing level of IL-6 and TNF-α in the plasma. Taken together, these results suggest that lycopene can attenuate LPS-induced inflammation and depression-like behaviors, which may be involved in regulating HO-1 in the hippocampus.

• Authors: Fang Zhang, Yanyan Fu, Xiaoyan Zhou, Wei Pan, Yue Shi, Mei Wang, Xunbao Zhang, Dashi Qi, Lei Li, Kai Ma, Renxian Tang, Kuiyang Zheng, Yuanjian Song
• Journal: Journal of neuroimmunology (J Neuroimmunol) Vol. 298 Pg. 1-8 (09 15 2016) ISSN: 1872-8421 [Electronic] Netherlands
• PMID: 27609268 (Publication Type: Journal Article)
• Copyright: Copyright © 2016 Elsevier B.V. All rights reserved.

Chemical References

• Antioxidants
• Interleukin-6
• Lipopolysaccharides
• Tumor Necrosis Factor-alpha
• Carotenoids
• Heme Oxygenase-1
• Lycopene

Topics

• Animals
• Antioxidants (therapeutic use)
• Carotenoids (therapeutic use)
• Depression (blood, drug therapy, etiology)
• Encephalitis (chemically induced, complications)
• Enzyme-Linked Immunosorbent Assay
• Gene Expression Regulation (drug effects)
• Heme Oxygenase-1 (metabolism)
• Hippocampus (drug effects, metabolism)
• Interleukin-6 (blood)
• Lipopolysaccharides (toxicity)
• Lycopene
• Mice
• Mice, Inbred ICR
• Tumor Necrosis Factor-alpha (blood)