Abstract | OBJECTIVE: METHOD: The therapeutic efficacy of topically applied LPIO was compared to that of standard-concentration povidone-iodine ointment ( SPIO) and non-treatment control, using a full-thickness skin- wound model in 24 hairless rats and a full-thickness skin-defect model in rabbit earlobes. The animals were kept under standardised conditions at the Central Research Laboratory of Maruishi Pharmaceutical Co. Ltd. (Osaka, Japan). Therapeutic efficacy was evaluated based on macroscopic wound-size reduction, as well as histopathological and immuno-histochemical examinations. RESULTS: LPIO enhanced wound healing in rat full-thickness skin ulcers, reducing wound size and inflammation, when compared with that in SPIO and non-treatment control. LPIO also markedly improved wound healing in rabbit earlobe ulcers by significantly improving re-epithelialisation, compared with that in SPIO. CONCLUSION: The results of this study suggest that LPIO is a useful topical therapy for ulcerative lesions.
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Authors | O Mitani, A Nishikawa, I Kurokawa, E C Gabazza, M Ikeda, H Mizutani |
Journal | Journal of wound care
(J Wound Care)
Vol. 25
Issue 9
Pg. 521-9
(Sep 2016)
ISSN: 0969-0700 [Print] England |
PMID | 27608513
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Ointments
- Petrolatum
- Povidone-Iodine
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Topics |
- Animals
- Anti-Infective Agents, Local
(pharmacology)
- Disease Models, Animal
- Ointments
- Petrolatum
(pharmacology)
- Povidone-Iodine
(pharmacology)
- Rabbits
- Rats
- Skin Ulcer
(drug therapy)
- Wound Healing
(drug effects)
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