Hypertension is the most common cardiovascular risk factor.
Lipoprotein(a) [Lp(a)],
inflammation, oxidative stress and
chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the
vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (
ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of
hypertension with Lp(a),
inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference,
creatinine, Lp(a),
inflammation and
malondialdehyde levels were significantly higher and CKD state in the
ndHT patients (p < 0.05). Multiple logistic regression showed
hypertension associated with increased Lp(a),
inflammation,
ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and
inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with
hypertension and implications for the increased risk of HT and
vascular disease.