Clinical application of SPECT-CT with 99mTc-Tektrotyd in bronchial and thymic neuroendocrine tumors (NETs).

Abstract

Neuroendocrine tumors (NETs) of the thorax including bronchial and thymic tumors belong to foregut NETs. Limited loco-regional thoracic NETs can be resected with surgery, but in extensive metastatic disease the treatment is mainly palliative. A high incidence and density of somatostatin receptors (SSTR2, SSTR3, and SSTR5) are found in thoracic NETs. The purpose of this study was to evaluate the role of SPECT-CT somatostatin receptor scintigraphy (SRS) with 99mTc-Tektrotyd for imaging, staging and follow up of patients with bronchial and thymic neuroendocrine tumors. Forty-one patients with thoracic tumors with neuroendocrine differentiation were studied. Sixty-eight examinations including SPECT-CT studies of the neck and chest and/or abdomen and pelvis were carried out 2-4 hrs. post i.v. administration of aver-age 740 MBq activity dose of 99mTc-EDDA/HYNIC-TOC (Tektrotyd, Polatom). In all 41 investigated patients we obtained 81.25% (13/16), 88% (22/25) and 85.36% (35/41) of sensitivity, specificity and accuracy of this diagnostic approach, respectively. Somatostatin-receptor scintigraphy correctly identified all primary NETs located in the lungs and thymus. SPECT-CT studies with 99mTc-EDDA/HYNIC-TOC resulted in exact pre-surgical and pre-treatment N/M staging of bronchial and thymic NETs, except 2 cases with multiple hepatic metastases and 1 with massive suprarenal metastasis. It can be concluded that SPECT-CT with 99mTc-EDDA/HYNIC-TOC is a valuable tool for staging and follow-up of patients with thoracic NETs.

• Authors: Sonya Sergieva, Bozhil Robev, Milena Dimcheva, Albena Fakirova, Radka Hristoskova
• Journal: Nuclear medicine review. Central & Eastern Europe (Nucl Med Rev Cent East Eur) Vol. 19 Issue 2 Pg. 81-7 ( 2016) ISSN: 1644-4345 [Electronic] Poland
• PMID: 27479885 (Publication Type: Journal Article)

Chemical References

• Organotechnetium Compounds
• technetium Tc 99m hydrazinonicotinyl-Tyr(3)-octreotide
• Octreotide

Topics

• Adult
• Bronchial Neoplasms (diagnostic imaging, pathology)
• Female
• Humans
• Male
• Middle Aged
• Neoplasm Metastasis
• Neoplasm Staging
• Neuroendocrine Tumors (diagnostic imaging, pathology)
• Octreotide (analogs & derivatives)
• Organotechnetium Compounds
• Sensitivity and Specificity
• Single Photon Emission Computed Tomography Computed Tomography
• Thymus Neoplasms (diagnostic imaging, pathology)