[An Elderly Patient with Multiple Lung Metastases after Colectomy Successfully Treated with a Combination Oral UFT/LV Chemotherapy Regimen].

Abstract

We report an 84-year-old woman with multiple lung metastases from sigmoid colon cancer successfully treated with an oral combination chemotherapeutic agent regimen(UFT/LV).The patient had undergone colectomy for sigmoid colon cancer. Histological examination confirmed a pT4a, pN3, pM1a(LYM), pStage IV tumor.The patient refused adjuvant chemotherapy. However, approximately 9 months postoperatively, she developed a severe cough.Chest radiography and computed tomography(CT)revealed multiple progressive lung metastases.Thereafter, considering her advanced age and general condition, an oral UFT/LV regimen(UFT 300mg/LV 75mg for 7 days every 14 days)was initiated.Two and a half months after initiating chemotherapy, symptom amelioration was observed.Chest radiography and CT showed disappearance of several of the lung metastases, indicating a Partial Response(PR).For the nearly one year to date since diagnosis, she has remained free of cough and the PR has been maintained without chemotherapy-associated adverse events.She is currently being managed on an outpatient basis.The oral UFT/LV regimen is considered to be among the potentially effective and safe treatments for elderly patients with postoperative metastases from colon cancer.

• Authors: Takehiro Shiraishi, Tomoyuki Moriya, Hideki Ueno, Eiji Shinto, Yoshiki Kajiwara, Takahiro Sueyama, Tomoki Watanabe, Masato Yamadera, Junji Yamamoto, Kazuo Hase
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 43 Issue 7 Pg. 901-3 (Jul 2016) ISSN: 0385-0684 [Print] Japan
• PMID: 27431638 (Publication Type: Case Reports, Journal Article)

Chemical References

• Tegafur
• Uracil
• Leucovorin

Topics

• Aged, 80 and over
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Colectomy
• Female
• Humans
• Leucovorin (administration & dosage)
• Lung Neoplasms (drug therapy, secondary)
• Sigmoid Neoplasms (drug therapy, pathology, surgery)
• Tegafur (administration & dosage)
• Treatment Outcome
• Uracil (administration & dosage)