Abstract | INTRODUCTION: METHODS: A total of 447 PD patients (PD patients without cognitive impairment: n = 187; PD patients with mild cognitive impairment: n = 188; PD patients with dementia: n = 72) were included from an ongoing observational German multicenter cohort study (LANDSCAPE study). All patients underwent an extensive neuropsychological test battery, including assessments of memory, visuospatial functioning, attention, language, and executive function. APOE genotype was determined by an allelic discrimination assay. Linear regression analysis was used to explore the associations between APOE-ε4 and cognitive performance. RESULTS: CONCLUSION:
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Authors | David Mengel, Judith Dams, Jannis Ziemek, Julian Becker, Monika Balzer-Geldsetzer, Rüdiger Hilker, Simon Baudrexel, Elke Kalbe, Nele Schmidt, Karsten Witt, Inga Liepelt-Scarfone, Susanne Gräber, Annette Petrelli, Petra Neuser, Claudia Schulte, Katharina Linse, Alexander Storch, Hans-Ulrich Wittchen, Oliver Riedel, Brit Mollenhauer, Jens Ebentheuer, Claudia Trenkwalder, Thomas Klockgether, Annika Spottke, Ullrich Wüllner, Jörg B Schulz, Kathrin Reetz, Ines Ann Heber, Alfredo Ramirez, Richard Dodel |
Journal | Parkinsonism & related disorders
(Parkinsonism Relat Disord)
Vol. 29
Pg. 112-6
(08 2016)
ISSN: 1873-5126 [Electronic] England |
PMID | 27321987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2016 Elsevier Ltd. All rights reserved. |
Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Apolipoprotein E4
(genetics)
- Cognition Disorders
(etiology, genetics)
- Cohort Studies
- DNA Mutational Analysis
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Neuropsychological Tests
- Parkinson Disease
(complications, genetics)
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