Abstract | BACKGROUND: OBJECTIVE: The aim of this study was to investigate the expression of COX-2 and its association with clinico-patholocigal parameters and survival in Tunisian GC patients and to correlate COX-2 expression with others cancer-related proteins. METHODS: The immunohistochemistry was used to study the expression of COX-2 on 93 patients with gastric adenocarcinoma. RESULTS: Our results show that COX-2 immunostaining is negative to weak in 51.6%, moderate in 33.3%, and intense in 15.1% of tumor tissues. The expression of COX-2 associated significantly with tumor differentiation (p = 0.003), and histological type (p = 0.039). Furthermore, lack of COX-2 expression is significantly associated with 1-year (p= 0.005), 2-years (p= 0.000), and 5-years (p= 0.042) relapse free survival. In addition, Cox regression model, revealed that metastasis (p= 0.014), tumor site (p= 0.013), histotype (p = 0.02), and COX-2 expression (p = 0.003) are independent factors for prognosis. Regarding the relationship between COX-2 and cancer related proteins, we found that COX-2 expression is positively associated with APC (p = 0.006), and P53 (p = 0.026), supporting a cross link between these proteins in gastric carcinogenesis. CONCLUSION: Our findings emphasize the importance of COX-2 as a potential marker of tumor progression and prognosis in GC, and that the inhibition of COX-2 activity may have a therapeutic benefit in GC.
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Authors | Dorra Ben Ayed-Guerfali, Slim Charfi, Abdelmajid Khabir, Tahia Sellami-Boudawara, Ali Gargouri, Raja Mokdad-Gargouri |
Journal | Cancer biomarkers : section A of Disease markers
(Cancer Biomark)
Vol. 17
Issue 1
Pg. 67-73
(Jun 07 2016)
ISSN: 1875-8592 [Electronic] Netherlands |
PMID | 27314294
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Adenocarcinoma
(diagnosis, genetics, mortality)
- Adult
- Aged
- Cyclooxygenase 2
(genetics, metabolism)
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Immunohistochemistry
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Neoplasm Grading
- Neoplasm Metastasis
- Neoplasm Staging
- Prognosis
- Proportional Hazards Models
- Retrospective Studies
- Reverse Transcriptase Polymerase Chain Reaction
- Stomach Neoplasms
(diagnosis, genetics, mortality)
- Tunisia
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